AK3 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-49393

Novus Biologicals, part of Bio-Techne
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NBP2-49393
NBP2-49393-25ul
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Key Product Details

Validated by

Orthogonal Validation

Species Reactivity

Validated:

Human

Predicted:

Mouse (92%), Rat (93%). Backed by our 100% Guarantee.

Applications

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all AK3 Antibodies »

Product Specifications

Immunogen

This antibody was developed against a recombinant protein corresponding to amino acids: GKGTVSSRITTHFELKHLSSGDLLRDNMLRGTEIGVLAKAFIDQGKLIPDDVMTRLALHELKNLTQYSWLLD

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for AK3 Antibody

Immunocytochemistry/ Immunofluorescence: AK3 Antibody [NBP2-49393]

Immunocytochemistry/ Immunofluorescence: AK3 Antibody [NBP2-49393]

Immunocytochemistry/Immunofluorescence: AK3 Antibody [NBP2-49393] - Staining of human cell line Hep G2 shows localization to mitochondria.
Immunohistochemistry-Paraffin: AK3 Antibody [NBP2-49393]

Immunohistochemistry-Paraffin: AK3 Antibody [NBP2-49393]

Immunohistochemistry-Paraffin: AK3 Antibody [NBP2-49393] - Staining of human pancreas shows low expression as expected.
Immunohistochemistry-Paraffin: AK3 Antibody [NBP2-49393]

Immunohistochemistry-Paraffin: AK3 Antibody [NBP2-49393]

Immunohistochemistry-Paraffin: AK3 Antibody [NBP2-49393] - Staining of human liver shows cytoplasmic positivity in hepatocytes.
View 2 more images

Applications for AK3 Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

0.25-2 ug/ml

Immunohistochemistry

1:500 - 1:1000

Immunohistochemistry-Paraffin

1:500 - 1:1000
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended. Immunocytochemistry/Immunofluorescence Fixation Permeabilization: Use PFA/Triton X-100.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: AK3

Adenylate kinase (AK; adenosine triphosphate-adenosine monophosphate [ATP-AMP] phospho-transferase, EC 2.7.4.3) is a ubiquitous monomeric enzyme involved energy metabolism of prokaryotic and eukaryotic cells. Three isozymes (AK1, AK2 and AK3) are characterized in vertebrates. AK1 is present in the cytosol of skeletal muscle, brain, and erythrocyte, while AK2 is localized in the intermembrane space of mitochondria of liver, kidney, spleen and heart. AK3, called GTP:AMP phosphotransferase, exists in the mitochondrial matrix of liver and heart. These isozymes contribute to homeostasis of the adenine nucleotide composition in the cell.

Long Name

GTP:AMP phosphotransferase AK3, mitochondrial

Alternate Names

Adenylate kinase 3, AK 3, AK3L1, AK6, AKL3L, EC 2.7.4.10

Gene Symbol

AK3

Additional AK3 Products

Product Documents for AK3 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for AK3 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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