ATIC Antibody (F38 P7 H9)

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-66607

Novus Biologicals, part of Bio-Techne
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NBP2-66607
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Key Product Details

Species Reactivity

Human, Mouse, Rat, Drosophila, Xenopus

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 Clone # F38 P7 H9

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all ATIC Antibodies »

Product Specifications

Immunogen

Hybridoma produced by the fusion of splenocytes from BALB/c mice immunized with a synthetic peptide derived from the human ATIC protein (Uniprot: P31939) and mouse myeloma Ag8563 cells.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Scientific Data Images for ATIC Antibody (F38 P7 H9)

ATIC Antibody (F38 P7 H9)

Immunohistochemistry: ATIC Antibody (F38 P7 H9) [NBP2-66607] -

Immunohistochemistry: ATIC Antibody (F38 P7 H9) [NBP2-66607] - Left and Center: Immunohistochemical staining of normal colon tissue and colon carcinoma tissue using ATIC antibody (Cat. No. NBP2-66607).Right: Western blot using ATIC antibody on HT29 cell lysate.

Applications for ATIC Antibody (F38 P7 H9)

Application
Recommended Usage

Immunohistochemistry

1 ug/ml

Immunohistochemistry-Paraffin

1-5 ug/ml

Western Blot

5-10 ug/ml
Application Notes
.

Formulation, Preparation, and Storage

Purification

Protein A or G purified

Formulation

PBS

Preservative

0.08% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: ATIC

The bifunctional purine biosynthesis protein PURH contains phosphoribosylaminoimidazole carboxamide formyltransferase, also designated AICAR transformylase, IMP cyclohydrolase or Inosinicase. AICAR plays an important role in purine biosynthesis, specifically in the production of nucleotides and IMP. Defects in ATIC, the gene encoding for this protein, can cause AICArebosuria, also designated AICA-ribosiduria, an inborn error in purine biosynthesis that is neurologically cataclysmic. Individuals with AICA-rebosuria accumulate AICA-ribotide, also designated ZMP, and its derivatives in erythrocytes and fibroblasts and also excrete very large amounts of AICA-riboside in the urine. Mental retardation, epilepsy, dysmorphic features and congenital blindness are all symptoms of this disease.

Alternate Names

5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMPcyclohydrolase, 5-aminoimidazole-4-carboxamide-1-beta-D-ribonucleotidetransformylase/inosinicase, AICAR, AICAR formyltransferase/IMP cyclohydrolase bifunctional enzyme, AICARFT, AICARFT/IMPCHASE, bifunctional purine biosynthesis protein PURH, IMPCHASE, phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase, PURHFLJ93545

Gene Symbol

ATIC

UniProt

P31939 (Human)

Additional ATIC Products

Product Documents for ATIC Antibody (F38 P7 H9)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for ATIC Antibody (F38 P7 H9)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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