(-)-Bicuculline methochloride

Name: (-)-Bicuculline methochloride
Brand: Tocris Bioscience
SKU: 0131
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 0131

Citations (218)

COA / SDS

GABAA antagonist; more water soluble version of (+)-bicuculline (Cat. No. 0130)

Key Product Details

Description:	GABA_A antagonist; more water soluble version of (+)-bicuculline (Cat. No. 0130)
Chemical Name:	[R-(R,S)]-5-(6,8-Dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquinolinium chloride
Purity:	≥99% (HPLC)
Molecular Weight:	417.85

View Full Technical Details for (-)-Bicuculline methochloride

Technical Data
Citations

Biological Activity for (-)-Bicuculline methochloride

(-)-Bicuculline methochloride is a methochloride salt of (+)-bicuculline. Water soluble and more stable than bicuculline. Non-GABA receptor-mediated actions reported.

Methoiodide Salt and Methobromide Salt also available.

Technical Data for (-)-Bicuculline methochloride

M. Wt	417.85
Formula	C₂₁H₂₀ClNO₆
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	38641-83-7
PubChem ID	10047593
InChi Key	RLJKFAMYSYWMND-GRTNUQQKSA-M
Smiles	[H][C@](C(C=CC6=C5OCO6)=C5C(O4)=O)4[C@]2([H])C1=CC3=C(OCO3)C=C1CC[N+](C)2C.[Cl-]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for (-)-Bicuculline methochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	41.78	100

Preparing Stock Solutions for (-)-Bicuculline methochloride

The following data is based on the product molecular weight 417.85.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.39 mL	11.97 mL	23.93 mL
5 mM	0.48 mL	2.39 mL	4.79 mL
10 mM	0.24 mL	1.20 mL	2.39 mL
50 mM	0.05 mL	0.24 mL	0.48 mL

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Reconstitution Calculator

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References for (-)-Bicuculline methochloride

References are publications that support the biological activity of the product.

Seutin Evidence for a non-GABAergic action of quaternary salts of bicuculline on DArgic neurones. Neuropharmacology 1997 PMID: 9517436
Seutin and Johnson Recent advances in the pharmacology of quaternary salts of bicuculline. TiPS 1999 PMID: 10390643
Kemp Quantitative evaluation of the potencies of GABA-receptor agonists and antagonists using the rat hippocampal slice preparation. Br.J.Pharmacol. 1986 PMID: 3011168