Finasteride

Name: Finasteride
Brand: Tocris Bioscience
SKU: 3293

Tocris Bioscience, part of Bio-Techne | Catalog # 3293

Citations (12)

COA / SDS

Type II 5α-reductase inhibitor

Key Product Details

Description:	Type II 5α-reductase inhibitor
Alternative Names:	MK 906
Chemical Name:	(5α,17β)-N-(1,1-Dimethylethyl)-3-oxo-4-azaandrost-1-ene-17-carboxamide
Purity:	≥99% (HPLC)
Molecular Weight:	372.54

View Full Technical Details for Finasteride

Technical Data
Citations

Biological Activity for Finasteride

Finasteride is an antiandrogen that inhibits type II 5α reductase (IC₅₀ = 65 nM). Suppresses the conversion of testosterone to dihydrotestosterone. Reduces prostatic dihydrotestosterone levels and prostate size in vivo. Orally active.

Technical Data for Finasteride

M. Wt	372.54
Formula	C₂₃H₃₆N₂O₂
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	98319-26-7
PubChem ID	57363
InChi Key	DBEPLOCGEIEOCV-WSBQPABSSA-N
Smiles	C[C@@]12[C@](CC[C@@H]2C(NC(C)(C)C)=O)([H])[C@]3([H])CC[C@@]4([H])NC(C=C[C@]4(C)[C@@]3([H])CC1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Finasteride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	37.25	100
	ethanol	37.25	100

Preparing Stock Solutions for Finasteride

The following data is based on the product molecular weight 372.54.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.68 mL	13.42 mL	26.84 mL
5 mM	0.54 mL	2.68 mL	5.37 mL
10 mM	0.27 mL	1.34 mL	2.68 mL
50 mM	0.05 mL	0.27 mL	0.54 mL

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Reconstitution Calculator

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References for Finasteride

References are publications that support the biological activity of the product.

Gao Comparison of the pharmacological effects of a novel selective androgen receptor modulator, the 5α-reductase inhibitor finasteride, and the antiandrogen hydroxyflutamide in intact rats: new approach for benign prostate hyperplasia. Endocrinology 2004 PMID: 15308613
Mukai Studies on neurosteroids XXV. Influence of a 5α-reductase inhibitor, finasteride, on rat brain neurosteroid levels and metabolism. Biol.Pharm.Bull. 2008 PMID: 18758053
Thigpen and Russell Four-amino acid segment in steroid 5α-reductase 1 confers sensitivity to finasteride, a competitive inhibitor. J.Biol.Chem. 1992 PMID: 1314830