Caspase-11/Caspase-4 Products
Caspase-11 (also known as Caspase-4) is a cysteine-aspartic acid protease that functions in apoptosis initiation and the activation of proinflammatory cytokines. Pro-Caspase-11 is expressed as a zymogen which is cleaved into two subunits, p20 and p10. It is activated by an autocatalytic mechanism or by Caspase-8-mediated cleavage in response to ER stress or bacterial infection. Its expression and activation can be induced by exposure to LPS.
Caspase-11 is one of several caspases associated with the inflammasome and plays an important role in the activation of proinflammatory cytokines. The active enzyme can cleave and activate Caspase-1 which in turn activates IL-1 beta.
3 results for "Caspase-11/Caspase-4" in Products
3 results for "Caspase-11/Caspase-4" in Products
Caspase-11/Caspase-4 Products
Caspase-11 (also known as Caspase-4) is a cysteine-aspartic acid protease that functions in apoptosis initiation and the activation of proinflammatory cytokines. Pro-Caspase-11 is expressed as a zymogen which is cleaved into two subunits, p20 and p10. It is activated by an autocatalytic mechanism or by Caspase-8-mediated cleavage in response to ER stress or bacterial infection. Its expression and activation can be induced by exposure to LPS.
Caspase-11 is one of several caspases associated with the inflammasome and plays an important role in the activation of proinflammatory cytokines. The active enzyme can cleave and activate Caspase-1 which in turn activates IL-1 beta.
Recombinant Monoclonal Antibody.
| Reactivity: | Mouse |
| Details: | Rabbit IgG Monoclonal Clone #1172C |
| Applications: | WB |
| Reactivity: | Mouse |
| Details: | Rat IgG2b Monoclonal Clone #919916 |
| Applications: | ICC |
Potent and selective inhibitor of caspases 1, 5 and 4
| Purity: | ≥95% |
