2,3-DCPE hydrochloride

Name: 2,3-DCPE hydrochloride
Brand: Tocris Bioscience
SKU: 2137

Tocris Bioscience, part of Bio-Techne | Catalog # 2137

Citations (2)

COA / SDS

Selectively induces cancer cell apoptosis

Key Product Details

Chemical Name:	2-[[3-(2,3-Dichlorophenoxy)propyl]amino]ethanol hydrochloride
Purity:	≥99%
Molecular Weight:	300.61 kDa

View Full Technical Details for 2,3-DCPE hydrochloride

Technical Data
Citations

Biological Activity for 2,3-DCPE hydrochloride

2,3-DCPE hydrochloride is a selectively induces apoptosis and downregulates Bcl-XL protein expression in various human cancer cells versus normal cells in vitro. IC₅₀ values are 0.89 and 12.6 μM for LoVo human colon cancer cell line and normal human fibroblasts respectively. Induces p21 expression and S-phase arrest in cancer cells via ERK-mediated pathways.

Technical Data for 2,3-DCPE hydrochloride

M. Wt	300.61 kDa
Formula	C₁₁H₁₅Cl₂NO₂.HCl
Storage	Desiccate at -20°C
Purity	≥99%
CAS Number	1009555-55-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for 2,3-DCPE hydrochloride

Solubility

Soluble Soluble to 100 mM in water

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References for 2,3-DCPE hydrochloride

References are publications that support the biological activity of the product.

Wu et al. Induction of apoptosis and down-regulation of Bcl-XL in cancer cells by a novel small molecule, 2[[3-(2,3-Dichlorophenoxy)propyl]amino]ethanol. Cancer Res., 2004;64:1110 PMID: 14871845
Zhu et al. Induction of S-phase arrest and p21 overexpression by a small molecule 2[[3-(2,3-dichlorophenoxy)propyl]amino]ethanol in correlation with activation of ERK. Oncogene, 2004;23:4984 PMID: 15122344