(+)-Anabasine hydrochloride

Name: (+)-Anabasine hydrochloride
Brand: Tocris Bioscience
SKU: 1971

Tocris Bioscience, part of Bio-Techne | Catalog # 1971

Citations (5)

COA / SDS

High affinity nAChR partial agonist

Key Product Details

Chemical Name:	(S)-(+)-3-(2-Piperidinyl)pyridine hydrochloride
Purity:	≥99%
Molecular Weight:	198.69 kDa

View Full Technical Details for (+)-Anabasine hydrochloride

Technical Data
Citations

Biological Activity for (+)-Anabasine hydrochloride

(+)-Anabasine hydrochloride is a high affinity neuronal nicotinic ACh receptor partial agonist (K_i values are 0.058, 0.26 and 7.2 μM for rat α7, rat α4β2 and fish skeletal muscle nAChRs respectively). Also stimulates Ca²⁺-dependent catecholamine release from rat adrenomedullary cells in vitro.

Technical Data for (+)-Anabasine hydrochloride

M. Wt	198.69 kDa
Formula	C₁₀H₁₄N₂.HCl
Storage	Desiccate at RT
Purity	≥99%
CAS Number	53912-89-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for (+)-Anabasine hydrochloride

Solubility

Soluble Soluble to 100 mM in water

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References for (+)-Anabasine hydrochloride

References are publications that support the biological activity of the product.

Kem et al. Anabaseine is a potent agonist on muscle and neuronal alpha-bungarotoxin-sensitive nicotinic receptors. J.Pharmacol.Exp.Ther., 1997;283:979 PMID: 9399967
Parker et al. Neuronal nicotinic receptor β2 and β4 subunits confer large differences in agonist binding affinity. Mol.Pharmacol., 1998;54:1132 PMID: 9855644
Lu et al. Desensitization of nicotinic agonist-induced [³H]γ-aminobutyric acid release from mouse brain synaptosomes is produced by subactivating concentrations of agonists. J.Pharmacol.Exp.Ther., 1999;291:1127 PMID: 10565833
Hong et al. Effect of anabasine on catecholamine secreation from the perfused rat adrenal medulla. J.Cardiol., 2007;50:351 PMID: 18186309