AS 1892802

Name: AS 1892802
Brand: Tocris Bioscience
SKU: 4927

Tocris Bioscience, part of Bio-Techne | Catalog # 4927

Citations (1)

COA / SDS

Potent ROCK inhibitor; orally bioavailable

Discontinued Product

4927 has been discontinued. View all Rho-kinase Inhibitors products.

Key Product Details

Description:	Potent ROCK inhibitor; orally bioavailable
Chemical Name:	N-[(1S)-2-Hydroxy-1-phenylethyl]-N'-[4-(4-pyridinyl)phenyl]-urea
Purity:	≥99% (HPLC)
Molecular Weight:	333.38

View Full Technical Details for AS 1892802

Technical Data
Citations

Biological Activity for AS 1892802

AS 1892802 is a potent, ATP-competitive ROCK inhibitor (IC₅₀ values are 52, 57 and 122 nM for human ROCK2, rat ROCK2 and human ROCK1 respectively by ELISA); also inhibits PKAC-α and PRKX (IC₅₀ values are 200 and 325 nM respectively). Exhibits analgesic effects in rat models of inflammatory (AIA) and noninflammatory (MIA) arthritic pain. Orally bioavailable.

Technical Data for AS 1892802

M. Wt	333.38
Formula	C₂₀H₁₉N₃O₂
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	928320-12-1
PubChem ID	46911016
InChi Key	WDTFYYZHMRBVHK-LJQANCHMSA-N
Smiles	O=C(N[C@H](CO)C3=CC=CC=C3)NC(C=C2)=CC=C2C1=CC=NC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for AS 1892802

References are publications that support the biological activity of the product.

Yoshimi Antinociceptive effects of AS1892802, a novel Rho kinase inhibitor, in rat models of inflammatory and noninflammatory arthritis. J.Pharmacol.Exp.Ther. 2010 PMID: 20534789
Li Fragment-based and structure-guided discovery and optimization of Rho kinase inhibitors. J.Med.Chem. 2012 PMID: 22272748

AS 1892802

Tocris Bioscience, part of Bio-Techne | Catalog # 4927

Key Product Details

Biological Activity for AS 1892802

Technical Data for AS 1892802

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for AS 1892802

Product Documents for AS 1892802

COA

Certificate of Analysis

SDS

CONTACT INFORMATION

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