FzM1.8

Name: FzM1.8
Brand: Tocris Bioscience
SKU: 6961

Tocris Bioscience, part of Bio-Techne | Catalog # 6961

Citations (1)

COA / SDS

Frizzled 4 allosteric agonist; exhibits biased signaling; preserves stemness

Key Product Details

Chemical Name:	3-Hydroxy-5-[[(2-Naphthalenylamino)carbonyl]amino]benzoic acid
Purity:	≥98%

View Full Technical Details for FzM1.8

Technical Data
Citations

Biological Activity for FzM1.8

FzM1.8 is a frizzled 4 allosteric agonist (pEC₅₀ = 6.4). Potentiates the β-catenin pathway in the absence of any WNT ligand, by biasing FZD4 signaling toward the FZD4/PI3K axis. Preserves stemness and promotes proliferation of undifferentiated cells.

Technical Data for FzM1.8

Formula	C₁₈H₁₄N₂O₄
Storage	Store at -20°C
Purity	≥98%
CAS Number	2204290-85-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for FzM1.8

Solubility

Soluble Soluble to 100 mM in DMSO

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References for FzM1.8

References are publications that support the biological activity of the product.

Riccio et al. A negative allosteric modulator of WNT receptor frizzled 4 switches into an allosteric agonist. Biochemistry, 2018;57:839 PMID: 29293331

FzM1.8

Tocris Bioscience, part of Bio-Techne | Catalog # 6961

Key Product Details

Biological Activity for FzM1.8

Technical Data for FzM1.8

Solubility for FzM1.8

Dilution Calculator

Reconstitution Calculator

References for FzM1.8

Product Documents for FzM1.8

COA

Certificate of Analysis

SDS

CONTACT INFORMATION

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