GSK'872

Name: GSK'872
Brand: Tocris Bioscience
SKU: 6492
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 6492

(2)

Citations (20)

COA / SDS

Potent and selective RIP3 kinase inhibitor

Key Product Details

Chemical Name:	N-5-Benzothiazolyl-6-[(1-methylethyl)sulfonyl]-4-quinolinamine
Purity:	≥98%

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Technical Data
Citations / Reviews (2)

Biological Activity for GSK'872

GSK'872 is a potent and selective receptor activating protein kinase 3 (RIP3) inhibitor (IC₅₀ = 1.3 nM). Exhibits >1000-fold selectivity for RIP3 over a panel of 300 other kinases including RIP1. Inhibits TNF-induced cell death in 3T3-SA cells and TLR3-induced necrosis in fibroblasts in vitro. Blocks necroptosis of primary human neutrophils from whole blood. Also induces apoptosis at higher concentrations (3 - 10 μM).

Technical Data for GSK'872

Formula	C₁₉H₁₇N₃O₂S₂
Storage	Store at -20°C
Purity	≥98%
CAS Number	1346546-69-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for GSK'872

Solubility

Soluble Soluble to 100 mM in DMSO and to 100 mM in ethanol

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References for GSK'872

References are publications that support the biological activity of the product.

Kaiser et al. Toll-like receptor 3-mediated necrosis via TRIF, RIP3, and MLKL. J.Biol.Chem., 2013;288:31268 PMID: 24019532
Mandal et al. RIP3 induces apoptosis independent of pronecrotic kinase activity. Mol.Cell, 2014;56:481 PMID: 25459880

GSK'872

Tocris Bioscience, part of Bio-Techne | Catalog # 6492

Key Product Details

Biological Activity for GSK'872

Technical Data for GSK'872

Solubility for GSK'872

Dilution Calculator

Reconstitution Calculator

References for GSK'872

Product Documents for GSK'872

COA

Certificate of Analysis

SDS

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