(+)-Igmesine hydrochloride

Name: (+)-Igmesine hydrochloride
Brand: Tocris Bioscience
SKU: 2332

Tocris Bioscience, part of Bio-Techne | Catalog # 2332

Citations (2)

COA / SDS

Selective σ1 ligand; antidepressant

Key Product Details

Description:	Selective σ₁ ligand; antidepressant
Chemical Name:	(R)-(+)-N-Cyclopropylmethyl-α-ethyl-N-methyl-α-[(2E)-3-phenyl-2-propenyl)benzenemethanamine hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	355.94

View Full Technical Details for (+)-Igmesine hydrochloride

Technical Data
Citations

Biological Activity for (+)-Igmesine hydrochloride

(+)-Igmesine hydrochloride is a selective σ₁ receptor ligand (K_D = 19.1 nM), with little or no activity at σ₂ receptors (IC₅₀ > 1000 nM). Inhibits the NMDA-induced increase in cGMP in a concentration-dependent manner (IC₅₀ value is approximately 100 nM). Weak inhibitor of brain 5-HT uptake in vitro. Exhibits neuroprotective and antidepressant effects.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Compound Libraries for (+)-Igmesine hydrochloride

(+)-Igmesine hydrochloride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for (+)-Igmesine hydrochloride

M. Wt	355.94
Formula	C₂₃H₂₉N.HCl
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	130152-35-1
PubChem ID	6438339
InChi Key	SCHQQPAJNUHKSV-RSGUCCNWSA-N
Smiles	CN(C(CC)(C3=CC=CC=C3)C/C=C/C2=CC=CC=C2)CC1CC1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for (+)-Igmesine hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	17.8	50

Preparing Stock Solutions for (+)-Igmesine hydrochloride

The following data is based on the product molecular weight 355.94.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.62 mL	28.09 mL	56.19 mL
2.5 mM	1.12 mL	5.62 mL	11.24 mL
5 mM	0.56 mL	2.81 mL	5.62 mL
25 mM	0.11 mL	0.56 mL	1.12 mL

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References for (+)-Igmesine hydrochloride

References are publications that support the biological activity of the product.

O'Neill The sigma receptor ligand JO 1784 (igmesine hydrochloride) is neuroprotective in the gerbil model of global cerebral ischaemia. Eur.J.Pharmacol. 1995 PMID: 7498313
Akunne Neuropharmacological profile of a selective sigma ligand, igmesine: a potential antidepressant. Neuropharmacology 2001 PMID: 11445194