L-755,507

Name: L-755,507
Brand: Tocris Bioscience
SKU: 2197

Tocris Bioscience, part of Bio-Techne | Catalog # 2197

Citations (13)

COA / SDS

Very potent and selective β3 partial agonist

Key Product Details

Chemical Name:	4-[[(Hexylamino)carbonyl]amino]-N-[4-[2-[[(2S)-2-hydroxy-3-(4-hydroxyphenoxy)propyl]amino]ethyl]phenyl]-benzenesulfonamide
Purity:	≥98%
Molecular Weight:	584.73 kDa

View Full Technical Details for L-755,507

Technical Data
Citations

Biological Activity for L-755,507

L-755,507 is a potent β₃-adrenergic receptor partial agonist > 1000-fold selective over β₁- and β₂-adrenoceptors (EC₅₀ values are 0.43, 580 and > 10000 nM for activation of cloned human β₃-, β₁- and β₂-adrenoceptors respectively). Stimulates lipolysis in rhesus adipocytes in vitro (EC₅₀ = 3.9 nM). Enhances CRISPR-mediated homology-directed repair (HDR) efficiency 2-3-fold for large fragments and ~9-fold for point mutations, in human induced pluripotent stem cells (iPSCs).

Technical Data for L-755,507

M. Wt	584.73 kDa
Formula	C₃₀H₄₀N₄O₆S
Storage	Store at +4°C
Purity	≥98%
CAS Number	159182-43-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for L-755,507

Solubility

Soluble Soluble to 100 mM in DMSO and to 100 mM in ethanol

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References for L-755,507

References are publications that support the biological activity of the product.

YY Sin, PR Price, LL Ballantyne, CD Funk Proof-of-Concept Gene Editing for the Murine Model of Inducible Arginase-1 Deficiency Sci Rep, 2017;7(1):2585. 2017 PMID: 28566761
Yu et al. Small molecules enhance CRISPR genome editing in pluripotent stem cells. Cell Stem Cell, 2015;16:142 PMID: 25658371
Parmee et al. Discovery of L-755,507: a subnanomolar human β₃ adrenergic receptor agonist. Bioorg.Med.Chem.Lett., 1998;8:1107 PMID: 9871717
Fisher et al. A selective human β₃ adrenergic receptor agonist increases metabolic rate in rhesus monkeys. J.Clin.Invest., 1998;101:2387 PMID: 9616210