Phosphoramidon disodium salt

Name: Phosphoramidon disodium salt
Brand: Tocris Bioscience
SKU: 6333

Tocris Bioscience, part of Bio-Techne | Catalog # 6333

Citations (5)

COA / SDS

Neutral endopeptidase and endothelin converting enzyme inhibitor

Key Product Details

Chemical Name:	N-[N-[[(6-Deoxy-α-L-mannopyranosyl)oxy]hydroxyphosphinyl]-L-leucyl]-L-tryptophan disodium salt
Purity:	≥95%

View Full Technical Details for Phosphoramidon disodium salt

Technical Data
Citations

Biological Activity for Phosphoramidon disodium salt

Phosphoramidon disodium salt is a neutral endopeptidase (neprilysin) inhibitor. Blocks degradation of amyloid β peptides and increases Aβ levels in rodents. Also blocks endothelin converting enzyme (ECE).

Technical Data for Phosphoramidon disodium salt

Formula	C₂₃H₃₂N₃Na₂O₁₀P
Storage	Store at -20°C
Purity	≥95%
CAS Number	164204-38-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Phosphoramidon disodium salt

Solubility

Soluble Soluble to 100 mM in water

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References for Phosphoramidon disodium salt

References are publications that support the biological activity of the product.

Y Hao, W Purtha, C Cortesio, H Rui, Y Gu, H Chen, EA Sickmier, P Manzanillo, X Huang Crystal structures of human procathepsin H PLoS ONE, 2018;13(7):e0200374. 2018 PMID: 30044821
Marr and Hafez Amyloid-beta and Alzheimer's disease: the role of neprilysin-2 in amyloid-beta clearance. Front.Aging Neurosci., 2014;6:187 PMID: 25165447
Shirotani et al. Neprilysin degrades both amyloid β peptides 1-40 and 1-42 most rapidly and efficiently among thiorphan- and phosphoramidon-sensitive endopeptidases. J.Biol.Chem., 2001;276:21895 PMID: 11278416
Warner et al. Regional differences in endothelin converting enzyme activity in rat brain: inhibition by phosphoramidon and EDTA. Br.J.Pharmacol., 1992;106:948 PMID: 1393292

Phosphoramidon disodium salt

Tocris Bioscience, part of Bio-Techne | Catalog # 6333

Key Product Details

Biological Activity for Phosphoramidon disodium salt

Technical Data for Phosphoramidon disodium salt

Solubility for Phosphoramidon disodium salt

Dilution Calculator

Reconstitution Calculator

References for Phosphoramidon disodium salt

Product Documents for Phosphoramidon disodium salt

COA

Certificate of Analysis

SDS

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