(±)-PPCC oxalate

Name: (±)-PPCC oxalate
Brand: Tocris Bioscience
SKU: 3870

Tocris Bioscience, part of Bio-Techne | Catalog # 3870

Citations (5)

COA / SDS

Selective sigma (σ) agonist (σ1> σ2)

Key Product Details

Chemical Name:	(1R,2S)-rel-2-[(4-Hydroxy-4-phenyl-1-piperidinyl)methyl]-1-(4-methylphenyl)-cyclopropanecarboxylic acid methyl ester oxalate
Purity:	≥99%
Molecular Weight:	469.53 kDa

View Full Technical Details for (±)-PPCC oxalate

Technical Data
Citations

Biological Activity for (±)-PPCC oxalate

(±)-PPCC oxalate is a selective sigma (σ) receptor ligand. Displays high affinity for σ₁; also binds at σ₂ sites (K_i = 1.5 nM and 50.8 nM respectively). Selective over a range of receptor types including dopaminergic and muscarinic receptors, DAT and SERT.

Technical Data for (±)-PPCC oxalate

M. Wt	469.53 kDa
Formula	C₂₄H₂₉NO₃.C₂H₂O₄
Storage	Store at +4°C
Purity	≥99%
CAS Number	1781628-91-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for (±)-PPCC oxalate

Solubility

Soluble Soluble to 100 mM in DMSO and to 10 mM in ethanol

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References for (±)-PPCC oxalate

References are publications that support the biological activity of the product.

Prezzavento et al. Novel sigma receptor ligands: synthesis and biological profile. J.Med.Chem., 2007;50:951 PMID: 17328523
Prezzavento et al. A new sigma ligand, (±)-PPCC, antagonizes kappa opioid receptor-mediated antinociceptive effect. Life Sci., 2008;82:549 PMID: 18261749
Antonini et al. Anti-amnesic properties of (±)-PPCC, a novel sigma receptor ligand, on cognitive dysfunction induced by selective cholinergic lesion in rats. J.Neurochem., 2009;109:744 PMID: 19245662