Ro 60-0175 fumarate

Name: Ro 60-0175 fumarate
Brand: Tocris Bioscience
SKU: 1854

Tocris Bioscience, part of Bio-Techne | Catalog # 1854

Citations (3)

COA / SDS

Potent, selective 5-HT2C agonist

Key Product Details

Description:	Potent, selective 5-HT_2C agonist
Chemical Name:	(αS)-6-Chloro-5-fluoro-α-methyl-1H-indole-1-ethanamine fumarate
Purity:	≥98% (HPLC)
Molecular Weight:	342.75

View Full Technical Details for Ro 60-0175 fumarate

Technical Data
Citations

Biological Activity for Ro 60-0175 fumarate

Ro 60-0175 fumarate is a potent, selective 5-HT₂ receptor agonist; shows selectivity for the 5-HT_2C subtype (pK_i values are 9, 7.5, 5.4, 5.2 and 5.6 for human 5-HT_2C, _2A, _1A, ₆ and ₇ receptors respectively). Centrally active following oral or systemic administration in vivo.

Compound Libraries for Ro 60-0175 fumarate

Ro 60-0175 fumarate is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Ro 60-0175 fumarate

M. Wt	342.75
Formula	C₁₁H₁₂ClFN₂.C₄H₄O₄
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	169675-09-6
PubChem ID	6446435
InChi Key	CEPHEXXZGQBXGT-XZTIXWOLSA-N
Smiles	O=C(O)/C=C/C(O)=O.FC1=C(Cl)C=C(N(C[C@H](C)N)C=C2)C2=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Ro 60-0175 fumarate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	1.71	5
	DMSO	6.86	20

Preparing Stock Solutions for Ro 60-0175 fumarate

The following data is based on the product molecular weight 342.75.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	14.59 mL	72.94 mL	145.88 mL
1 mM	2.92 mL	14.59 mL	29.18 mL
2 mM	1.46 mL	7.29 mL	14.59 mL
10 mM	0.29 mL	1.46 mL	2.92 mL

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References for Ro 60-0175 fumarate

References are publications that support the biological activity of the product.

Jensen Design, synthesis, and pharmacological characterization of N- and O-substituted 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-d]azepin-3-ol analogues: novel 5-HT2A/5-HT2C receptor agonists with pro-cognitive J.Med.Chem. 2013 PMID: 23301527
Kennett Effects of Ro 60 0175, a 5-HT_2C receptor agonist, in three animal models of anxiety. Eur.J.Pharmacol. 2000 PMID: 10650160
Martin 5-HT_2C receptor agonists: pharmacological characteristics and therapeutic potential. J.Pharmacol.Exp.Ther. 1998 PMID: 9694950
Damjanoska Neuroendocrine evidence that (S)-2-(chloro-5-fluoro-indol-l-yl)-1-methylethylamine fumarate (Ro 60-0175) is not a selective 5-hydroxytryptamine_2C receptor agonist. J.Pharmacol.Exp.Ther. 2003 PMID: 12604698