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What is Armored RNA Technology?

Armored RNA® and Armored DNA technologies stabilize and protect nucleic acids from nuclease degradation by packaging them in a protective protein coat. Armored reagents deliver several end-user benefits, including:

Optimized Workflow

Armored RNA, Armored RNA Quant and Armored DNA Quant controls can be added directly to human matrices as an exogenous internal control for extraction with most nucleic acid isolation methods and detection in molecular assays.

Flexibility

Nuclease-resistant protein coat can also be removed by heat lysis for direct detection as a positive run control. For Armored RNA Quant and Armored DNA Quant, analytical quantification is performed with a validated method referencing a NIST-traceable phosphate standard.

Download our Molecular Quality Controls Catalog

Catalog of Armored RNA and Armored DNA Products

 

Armored RNA Quant®

Each control encodes in vitro transcribed RNA encapsulated in a protective protein coat to create a virus-like particle resistant to nuclease degradation.

SARS-CoV-2

Description Part # Configuration
Targets the Nucleocapsid 1 and Nucleocapsid 2 regions of the CDC recommended Diagnostic Panel (CDC-006-00019). 52151 1x106 cp/mL
250μL

SARS-CoV-2 Panel

Description Part # Configuration
Contains multiple regions of SARS-Cov-2 genome including nucleocapsid, envelope, RNA-dependent RNA polymerase, open reading frame 1, and human RNAse P as an internal control. 52153 1x106 cp/mL
250μL

SARS-CoV-2 Spike Variants

Description Part # Configuration
Targets mutations in the SARS CoV-2 spike protein prevalent in the Alpha (B.1.1.7), Beta (B.1.351), Gamma (B.1.1.28), Delta (B.1.617.2), and Omicron (B.1.1.529) strains.

52160/52154

1x106 cp/mL
250μL

Respiratory Triplex

Description Part # Configuration
Contains regions of SARS-Cov-2, Influenza A (H1N1, H3N2, and H7N9), Influenza B, Respiratory Syncytial Virus A (RSVA), Respiratory Syncytial Virus B (RSVB), and RPP30 as an internal control. 52108 1x108 cp/mL
250μL

Armored RNA Quant® EPA 1615 Controls

Description Part # Configuration
Contains sequences detected by the Enterovirus, Norwalk GI, and Norwalk GII virus assays described in EPA Method 1615 - Measurement of Enterovirus and Norovirus occurrence in water by culture and RT-qPCR. 52000 1x1012 cp/mL
500μL

Enterovirus

Description Part # Configuration
Contains sequences amplified by primer binding regions for polio virus (type I Sabin), coxsackievirus A and coxsackievirus B (Schwab, et al., 1995 and Rotbart, 1990). 42102 5x105 cp/mL
5x100μL

Download Enterovirus PDF

Pentavalent Arbovirus Control

(CHIKV,DENV,WNV,YFV,ZIKV)
Description Part # Configuration
Targets regions of the Chikungunya, Dengue, West Nile, Yellow Fever, and Zika viruses. 49659 1x108 cp/mL
500μL

Zika Virus

Description Part # Configuration
Targets regions of the Zika virus. 49610 5x105 cp/mL
500μL

Internal Process Control (Armored RNA Quant)

Description Part # Configuration
Targets a non-specific, 1,000 nucleotides in vitro transcribed RNA (non-homologous) sequence intended to be used as a spike-in to sample (e.g., urine, blood, CSF, plasma/liquid biopsy) to monitor the overall efficiency of a testing process.  49650 2x106 cp/mL
500μL

Download the Internal Process Control PDF

RNase P

Description Part # Configuration
Targets the human RNase P gene; often used as an internal control because abundant copies in the human genome make it readily detectable. 52152 1x106 cp/mL
500μL

Armored DNA Quant

Armored DNA  technology stabilizes and protects nucleic acids from nuclease degradation by packaging them in a protective protein coat. Encapsulated as non-infectious, nuclease-resistant, pseudo-viral particle.

Mpox Nonvariola Orthopox Control

Description Part # Configuration
A single, concatenated construct of both nonvariola Orthopox and Mpox-specific sequence blended with with RNAse P to allow for an all-in-one process control. The control is provided as two tubes of high and low concentration along with diluent for convenience. 49670 500μL

Internal Process Control (Armored DNA Quant)

Description Part # Configuration
Targets a non-specific, 495 base pair in vitro transcribed DNA (non-homologous) sequence intended to be used as a spike-in to sample (e.g., urine, blood, CSF, plasma/liquid biopsy) to monitor the overall efficiency of a testing process. 52003 1x108 cp/mL
500μL

Armored RNA®

Hepatitis G Virus

Description Part # Configuration
Contains sequences amplified by primer binding regions for Hepatitis G Virus (Schlueter, 1996); the PCR product generated is 185 nucleotides. 42024 250μL

Download the Hepatitis G Virus PDF

Enterovirus

Description Part # Configuration
Contains sequences amplified by primer binding regions for polio virus (type I Sabin), coxsackievirus A and coxsackievirus B (Schwab, et al., 1995 and Rotbart, 1990). 42050 250μL

Download the Enterovirus PDF

Armored RNA Quant Made-to-Order

Bacteriophage MS2

Description Part # Configuration
Bacteriophage MS2 52223  

Beta-Actin (ACTB)

Description Part # Configuration
Beta-Actin (ACTB) 52225  

Ebolavirus

Description Part # Configuration
Ebolavirus 52217  

Glucuronidase Beta (GUSB)

Description Part # Configuration
Glucuronidase Beta (GUSB) 52224  

Hepatitis C Virus (GT 2b)

Description Part # Configuration
Hepatitis C Virus (GT 2b) 42101  

Download the Hepatitis C Virus (GT 2b) PDF

Hepatitis D Virus

Description Part # Configuration
Hepatitis D Virus 52212  

HIV (Subtype B)

Description Part # Configuration
HIV (Subtype B) 42103  

Human Papillomavirus 16

Description Part # Configuration
Human Papillomavirus 16 52219  

Human Papillomavirus 18

Description Part # Configuration
Human Papillomavirus 18 52220  

Sapovirus I, II, IV

Description Part # Configuration
Sapovirus I, II, IV 52221  

Sapovirus V

Description Part # Configuration
Sapovirus V 52222  

Sudan Ebolavirus

Description Part # Configuration
Sudan Ebolavirus 52218  

Armored RNA® Made-to-Order

Dengue Virus (Type I)

Description Part # Configuration
Dengue Virus (Type I) 42044  

Hepatitis C Virus (GT 1a)

Description Part # Configuration
Hepatitis C Virus (GT 1a) 42004  

Hepatitis C Virus (GT 1b)

Description Part # Configuration
Hepatitis C Virus (GT 1b) 42006  

Hepatitis C Virus (GT 2a/c)

Description Part # Configuration
Hepatitis C Virus (GT 2a/c) 42008  

Hepatitis C Virus (GT 2b)

Description Part # Configuration
Hepatitis C Virus (GT 2b) 42010  

Hepatitis C Virus (GT 3a)

Description Part # Configuration
Hepatitis C Virus (GT 3a) 42012  

HIV (Subtype B)

Description Part # Configuration
HIV (Subtype B) 42000  

Norovirus GI

Description Part # Configuration
Norovirus GI 42030  

Norovirus GII

Description Part # Configuration
Norovirus GII 42032  

SARS (BNI-1)

Description Part # Configuration
SARS (BNI-1) 42090  

SARS (CoV-NC)

Description Part # Configuration
SARS (CoV-NC) 42091  

West Nile Virus (Cap)

Description Part # Configuration
West Nile Virus (Cap) 42042  

West Nile Virus (HNY1999)

Description Part # Configuration
West Nile Virus (HNY1999) 42040  

West Nile Virus (NEN)

Description Part # Configuration
West Nile Virus (NEN) 42041  

Molecular Assay Reagents

RNARetain Buffer

Description Part # Configuration
Intended for the collection, storage, and transportation of fresh tissue specimens for subsequent RNA isolation and further molecular testing. Eliminates the need to immediately process specimens, enabling RNA extraction and molecular testing at a later time and/or transport to a different location. 49536 Volume 2L

Variable concentrations, volumes and vial quantities available upon request

TSMIII Buffer

Description Part # Configuration
A buffered solution ideally suited for the dilution of Armored products. The additives provide stability to the protein-coated nucleic acid through multiple freeze-thaws when stored properly, allowing for more flexible and scalable testing processes. 49600 Volume 50mL

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