Alzheimer's Disease Product Guide

Alzheimer’s disease is a progressive neurodegenerative disorder characterized by a loss of cognitive function. It is the most common neurodegenerative disease and it affects regions of the brain involved in higher functions such as sensory perception, language and memory. Symptoms include short-term memory loss, confusion and irritability, which progress to further memory deficits, loss of higher cognitive function and death. At present there is no cure for Alzheimer’s disease and no approved disease-modifying drugs; therapeutic options are limited and alleviate symptoms only.

The molecular mechanisms behind the pathophysiology of Alzheimer’s disease are not well defined, although there are several major hypotheses - these are summarized in this product guide, as well as the following featured topics and more:

• The amyloid cascade, tau and cholinergic hypotheses
• Mitochondrial dysfunction
• Theory of excitotoxicity
• Emerging treatment targets
• Cell and gene therapies
• Around 100 products for Alzheimer’s disease research