CACNB4 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-83984

Novus Biologicals, part of Bio-Techne
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NBP1-83984
NBP1-83984-25ul
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Mouse (98%), Rat (98%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all CACNB4 Antibodies »

Product Summary for CACNB4 Antibody

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: EHLGEYLEAYWRATHTTSSTPMTPLLGRNLGSTALSPYPTAISGLQSQRMRHSNHSTENSPIERRSLMTSDENYHNERARKSRNRLSSSSQHSRDHYPLVEEDYPDS

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for CACNB4 Antibody

Western Blot: CACNB4 Antibody [NBP1-83984]

Western Blot: CACNB4 Antibody [NBP1-83984]

Western Blot: CACNB4 Antibody [NBP1-83984] - Analysis in control (vector only transfected HEK293T lysate) and CACNB4 over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (3.1 kDa) in mammalian HEK293T cells).
Immunohistochemistry-Paraffin: CACNB4 Antibody [NBP1-83984]

Immunohistochemistry-Paraffin: CACNB4 Antibody [NBP1-83984]

Immunohistochemistry-Paraffin: CACNB4 Antibody [NBP1-83984] - Staining of human cerebellum shows strong cytoplasmic positivity in most cells.

Applications for CACNB4 Antibody

Application
Recommended Usage

Immunohistochemistry

1:50 - 1:200

Immunohistochemistry-Paraffin

1:50 - 1:200

Western Blot

0.04-0.4 ug/ml
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: CACNB4

CACNB4 encodes a member of the beta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. The protein described in this record plays an important role in calcium channel function by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Certain mutations in this gene have been associated with idiopathic generalized epilepsy (IGE) and juvenile myoclonic epilepsy (JME). Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized.

Long Name

Voltage-dependent L-type calcium channel subunit beta-4

Alternate Names

CAB4, CACNLB4

Gene Symbol

CACNB4

Additional CACNB4 Products

Product Documents for CACNB4 Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for CACNB4 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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