DISC1 [p Ser710] Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-23278

Novus Biologicals, part of Bio-Techne
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NBP3-23278
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Key Product Details

Validated by

Biological Validation

Species Reactivity

Validated:

Mouse, Rat

Applications

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all DISC1 Antibodies »

Product Summary for DISC1 [p Ser710] Antibody

Immunogen

Phospho-DISC1 (Ser-710) synthetic peptide (coupled to KLH) corresponding to amino acid residues surrounding Ser-710 in mouse DISC1. This peptide sequence is well conserved in rat DISC1 (Ser-703), but has five amino acid differences with the conserved site in human DISC1 (Ser-713). [UniProt# Q811T9]

Modification

p Ser710

Specificity

The antibody detects a 100 kDa protein corresponding to the molecular mass of DISC1 on SDS-PAGE immunoblots of PC12 cells treated with calyculin A. This reactivity is not observed after lambda phosphatase treatment.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

100 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Description

Stable for at least 1 year at -20°C.

Scientific Data Images for DISC1 [p Ser710] Antibody

DISC1 [p Ser710] Antibody

Western Blot: DISC1 [p Ser710] Antibody [NBP3-23278] -

Western Blot: DISC1 [p Ser710] Antibody [NBP3-23278] - Western blot of DISC1 phosphorylation in PC12 cells untreated (lanes 1 & 3) or treated with calyculin A (100 nm) for 30 min (lanes 2 & 4). The blots were probed with NBP3-23277 anti-DISC1 (a.a. 740-753) (lanes 1 & 2) or NBP3-23278 anti-DISC1 (Ser-710) (lanes 3 & 4).

Applications for DISC1 [p Ser710] Antibody

Application
Recommended Usage

Western Blot

1:1000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Antigen Affinity-purified

Formulation

PBS, 1 mg/ml BSA and 50% glycerol

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C.

Background: DISC1

The Disrupted In Schizophrenia gene locus DISC is associated with patients afflicted with schizophrenia as a result of chromosomal translocations. DISC-1 encodes a large protein predicted to contain a globular N-terminal domain and a helical C-terminal domain, both of which have the potential to form interactions with other proteins. DISC-1 interacts with proteins involved in the centrosome and cytoskeletal system, including MIPT3, MAP1A and NUDEL; proteins which localize receptors to membranes, including alpha-actinin 2 an beta 4-spectrin; and proteins which transduce signals from membrane receptors, including ATF-4 and ATF-5. Therefore, DISC-1 is thought to be involved in intracellular transport, neurite architecture and/or neuronal migration, all of which are thought to be pathogenic in the schizophrenic brain.

Long Name

Disrupted in Schizophrenia 1

Alternate Names

C1orf136, SCZD9

Gene Symbol

DISC1

Additional DISC1 Products

Product Documents for DISC1 [p Ser710] Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for DISC1 [p Ser710] Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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