FKBP52/FKBP4 Antibody (S08-4F8)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-19864

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-19864-100ul
NBP3-19864-50ul
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Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # S08-4F8

Concentration

0.3 mg/ml

View all FKBP52 Antibodies »

Product Summary for FKBP52/FKBP4 Antibody (S08-4F8)

Immunogen

A synthetic peptide of human FKBP52/FKBP4 (Uniprot # Q02790)

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

52 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for FKBP52/FKBP4 Antibody (S08-4F8)

Western Blot: FKBP52/FKBP4 Antibody (S08-4F8) [NBP3-19864]

Western Blot: FKBP52/FKBP4 Antibody (S08-4F8) [NBP3-19864]

Western Blot: FKBP52/FKBP4 Antibody (S08-4F8) [NBP3-19864] - Western blot detection of FKBP52/FKBP4 in U2OS, C6 using NBP3-19864 (1:1000 diluted)
Immunohistochemistry-Paraffin: FKBP52/FKBP4 Antibody (S08-4F8) [NBP3-19864]

Immunohistochemistry-Paraffin: FKBP52/FKBP4 Antibody (S08-4F8) [NBP3-19864]

Immunohistochemistry-Paraffin: FKBP52/FKBP4 Antibody (S08-4F8) [NBP3-19864] - Immunohistochemistry of FKBP52/FKBP4 in paraffin-embedded Human lung cancer tissue using NBP3-19864 at dilution 1/50

Applications for FKBP52/FKBP4 Antibody (S08-4F8)

Application
Recommended Usage

Immunohistochemistry

1/200

Western Blot

1/1000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.05% BSA

Preservative

0.01% Sodium Azide

Concentration

0.3 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: FKBP52

Hsp90 is crucial to cellular signaling by its regulation of the folding, activity, and stability of a wide range of client proteins. These client protein complexes may also contain one or more cochaperones (1). One class of Hsp90-binding cochaperone is composed of proteins with a characteristic tetratricopeptide repeat (TPR) domain that forms an Hsp90 binding site. Among the TPR cochaperones of Hsp90 are Hop/Sti1, protein phosphatase PP5, and members of both the FK506- and cyclosporin Abinding families of immunophilins (2). FK506-binding protein 51 (FKBP51) and FKBP52 are large molecular weight immunophilins that are part of the mature glucocorticoid receptor (GR) heterocomplex (3). The N terminal domain of each protein binds FK506 and has peptidyl-prolyl isomerase (PPIase) activity that converts prolyl peptide bonds within target proteins from cis- to trans- proline. The C-terminal domains contain the TPR repeats involved in protein-protein interactions with the Hsp90 (4). Although FKBP52 and FKBP51 share approx. 75% sequence similarity, they affect hormone binding by glucocorticoid receptor in opposing manners and have different Hsp90- binding characteristics (3, 5). Also, whereas FKBP51 typically has a role with the progesterone receptor, FKBP52 has been found to be linked to the progesterone, androgen and glucocorticoid receptors (5).

Long Name

52 kDa FK506 Binding Protein

Alternate Names

FKBP4, FKBP59, HBI, Hsp56

Gene Symbol

FKBP4

Additional FKBP52 Products

Product Documents for FKBP52/FKBP4 Antibody (S08-4F8)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for FKBP52/FKBP4 Antibody (S08-4F8)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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