Human Bax aa 3-16 Antibody

Bio-Techne includes R&D Systems | Catalog # 2282-MC

Discontinued Product
2282-MC has been discontinued. View all Bax products.

Key Product Details

Species Reactivity

Validated:

Human

Cited:

Human

Applications

Validated:

Immunoprecipitation, Western Blot

Cited:

Immunoprecipitation, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 Clone # YTH-2D2

View all Bax Antibodies »

Product Summary for Human Bax aa 3-16 Antibody

Immunogen

Human Bax
aa 3-16

Specificity

Anti-Bax (Clone YTH-2D2) cross reacts with human Bax.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Applications for Human Bax aa 3-16 Antibody

Application
Recommended Usage

Immunoprecipitation

Western Blot

1:1000 dilution
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A or G purified from hybridoma culture supernatant

Formulation

This antibody is provided as purified immunoglobulin from mouse ascites in 1X PBS containing 0.01% sodium azide.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4 °C.

Background: Bax

The Bcl-2 family of proteins plays a crucial role in the regulation of cell death in many eukaryotic systems. Bax has been shown to redistribute from the cytosol to the mitochondria during apoptosis, and overexpression of Bax can accelerate cell death. Coregulation of Bax dimer formation and intracellular localization are associated with Bax conformational changes. Anti-Bax YTH-2D2 is specific for human Bax and does not crossreact with mouse or rat Bax. When used in conjunction with the anti-Bax YTH-6A7 (Catalog # 2281-MC), which recognizes only detergent treated Bax, the researcher may selectively identify the activated form of Bax.

References

  1. Suzuki, M. et al. 2000, Cell 103:645-54.
  2. Hsu, Y.-T. et al. 1997, Proc. Natl. Acad. Sci. USA 94:3668-3672.
  3. Hsu, Y.-T. and R.J. Youle. 1997, J. Biol. Chem. 272:13829-13834.
  4. Neuchushtan, A. et al. 1999, EMBO J. 18:2330-2341.

Long Name

Bcl Associated X Protein

Alternate Names

apoptosis regulator BAX, BCL2-associated X protein, Bcl2-L-4, BCL2L4bcl2-L-4, Bcl-2-like protein 4

Entrez Gene IDs

581 (Human); 12028 (Mouse); 24887 (Rat)

Gene Symbol

BAX

Additional Bax Products

Product Documents for Human Bax aa 3-16 Antibody

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Note: Certificate of Analysis not available for kit components.

Product Specific Notices for Human Bax aa 3-16 Antibody

For research use only

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