Human CD161 PE-conjugated Antibody

R&D Systems, part of Bio-Techne | Catalog # FAB7448P

R&D Systems, part of Bio-Techne
Discontinued Product
FAB7448P has been discontinued. View all CD161 products.

Key Product Details

Species Reactivity

Human

Applications

Flow Cytometry

Label

Phycoerythrin (Excitation = 488 nm, Emission = 565-605 nm)

Antibody Source

Monoclonal Mouse IgG2B Clone # 702228

View all CD161 Antibodies »

Product Specifications

Immunogen

BaF3 mouse pro-B cell line transfected with human CD161
Accession # Q12918

Specificity

Detects human CD161 in direct ELISAs.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2B

Scientific Data Images for Human CD161 PE-conjugated Antibody

Detection of CD161 antibody in Human PBMCs antibody by Flow Cytometry.

Detection of CD161 in Human PBMCs by Flow Cytometry.

Human peripheral blood mononuclear cells (PBMCs) were stained with Mouse Anti-Human CD161 PE-conjugated Monoclonal Antibody (Catalog # FAB7448P) and Mouse Anti-Human CD4 Fluorescein-conjugated Monoclonal Antibody (Catalog # FAB3791F). View our protocol for Staining Membrane-associated Proteins.

Applications for Human CD161 PE-conjugated Antibody

Application
Recommended Usage

Flow Cytometry

10 µL/106 cells
Sample: Human peripheral blood mononuclear cells (PBMCs)

Formulation, Preparation, and Storage

Purification

Protein A or G purified from hybridoma culture supernatant

Formulation

Supplied in a saline solution containing BSA and Sodium Azide.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.

Background: CD161

CD161, also known as NKR-P1A and KLRB1, is a 40 kDa type II transmembrane glycoprotein that contains one C-type lectin domain in its extracellular region. CD161 is expressed as a disulfide-linked dimer on the surface of Th17 cells and NK cells as well as on subsets of CD1-restricted T cells, intestinal NT cells, peripheral memory T cells, monocytes, and dendritic cells. It binds to OCIL/CLEC2d, leading to an inhibition of NK cell-mediated cytotoxicity and IFN-g secretion. Alternatively, CD161 can enhance TCR activation to CD1d ligation. CD161+ cell populations are depleted in ulcerative colitis, Grave’s disease, and AIDS, although CD161+ T cells are activated during asthmatic attacks. Additional related proteins are expressed in mouse but not human: the inhibitory NKR‑P1B and D, and the stimulatory NKR‑P1A, C, and F. Human CD161 shares 47% aa sequence identity with mouse and rat NKR-P1A.

Alternate Names

CD161, CLEC5B, KLRB1, Ly59, NKR, NKRP1, NKRP1A

Entrez Gene IDs

3820 (Human); 25192 (Rat)

Gene Symbol

KLRB1

UniProt

Q12918

Additional CD161 Products

Product Documents for Human CD161 PE-conjugated Antibody

Product Datasheets

Certificate of Analysis

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Note: Certificate of Analysis not available for kit components.

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Product Specific Notices for Human CD161 PE-conjugated Antibody

For research use only

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