Mer Antibody (S07-6H2)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-14954

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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Key Product Details

Species Reactivity

Validated:

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # S07-6H2

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all Mer Antibodies »

Product Summary for Mer Antibody (S07-6H2)

Immunogen

A synthetic peptide of human Mer (Uniprot#: Q12866)

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

210 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for Mer Antibody (S07-6H2)

Western Blot: Mer Antibody (S07-6H2) [NBP3-14954]

Western Blot: Mer Antibody (S07-6H2) [NBP3-14954]

Western Blot: Mer Antibody (S07-6H2) [NBP3-14954] - Western blot detection of Mer in MCF-7, 293T cell lysates using Mer Rabbit mAb (1:1000 diluted). Predicted band size: 110kDa. Observed band size: 210kDa.
Immunohistochemistry-Paraffin: Mer Antibody (S07-6H2) [NBP3-14954]

Immunohistochemistry-Paraffin: Mer Antibody (S07-6H2) [NBP3-14954]

Immunohistochemistry-Paraffin: Mer Antibody (S07-6H2) [NBP3-14954] - Immunohistochemistry of Mer in paraffin-embedded Human tonsil using Mer Rabbit mAb at dilution 1/50

Applications for Mer Antibody (S07-6H2)

Application
Recommended Usage

Immunohistochemistry

1/50-1/500

Western Blot

1/1000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40% Glycerol, 0.05% BSA

Preservative

0.01% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Mer

MerTK (c-mer, Nyk, Eyk) is a tyrosine kinase that belongs to a family of transmembrane receptors (1). MerTk has been implicated in reversible cell growth arrest, survival, proliferation and cell adhesion. Growth arrest specific protein 6 (Gas6) is an activating ligand for MerTK (2-3). MerTK is required for clearance of apoptotic cells by mononuclear phagocytes in mice; with its absence resulting in progressive lupus like autoimmunity (4). Defects in MERTK are a cause of retinitis pigmentosa (RP) (5).

Long Name

Receptor Tyrosine Protein Kinase Mer

Alternate Names

c-Eyk, C-mer, MerTK

Gene Symbol

MERTK

Additional Mer Products

Product Documents for Mer Antibody (S07-6H2)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Mer Antibody (S07-6H2)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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