RGS19 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-24516

Novus Biologicals, part of Bio-Techne
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NBP2-24516
NBP2-24516SS
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Key Product Details

Species Reactivity

Validated:

Human, Mouse

Predicted:

Monkey (94%), Rat (95%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

0.5 mg/ml

View all RGS19 Antibodies »

Product Specifications

Immunogen

A portion of amino acids 1-50 of human RGS19 was used as the immunogen.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for RGS19 Antibody

Western Blot: RGS19 Antibody [NBP2-24516]

Western Blot: RGS19 Antibody [NBP2-24516]

Western Blot: RGS19 Antibody [NBP2-24516] - Analysis of RGS19 in mouse placenta lysate in the 1) absence and 2) presence of immunizing peptide using NBP2-24516 at 1.0 ug/ml.
Immunohistochemistry-Paraffin: RGS19 Antibody [NBP2-24516]

Immunohistochemistry-Paraffin: RGS19 Antibody [NBP2-24516]

Immunohistochemistry-Paraffin: RGS19 Antibody [NBP2-24516] - analysis of RGS19 in paraffin-embedded formalin-fixed human liver tissue using an isotype control (top) and this antibody (bottom) at 5 ug/ml.

Applications for RGS19 Antibody

Application
Recommended Usage

Immunohistochemistry-Paraffin

5 ug/ml

Western Blot

0.5-2 ug/ml
Application Notes
In addition to the expected approximately 25 kD band in western blot, additional bands are seen at approximately 45 and 65 kD in Ramos cell lysate.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

0.2 ml PBS and 0.05% BSA

Preservative

0.05% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: RGS19

G proteins mediate a number of cellular processes. The protein encoded by this gene belongs to the RGS (regulators of G-protein signaling) family and specifically interacts with G protein, GAI3. This protein is a guanosine triphosphatase-activating protein that functions to down-regulate Galpha i/Galpha q-linked signaling. Alternatively spliced transcript variants encoding the same protein isoform have been found for this gene.; FUNCTION: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, with the order G(i)a3 > G(i)a1 > G(o)a >> G(z)a/G(i)a2. Activity on G(z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein. SUBCELLULAR LOCATION: Membrane; Lipid-anchor. TISSUE SPECIFICITY: Highest expression in lung. Placenta, liver and heart also express high levels of GAIP.

Alternate Names

G alpha interacting protein, GAIPG protein signalling regulator 19, G-alpha-interacting protein, GNAI3IP, guanine nucleotide binding protein alpha inhibiting activity polypeptide 3interacting protein, regulator of G-protein signaling 19, regulator of G-protein signalling 19, RGSGAIP

Gene Symbol

RGS19

UniProt

P49795 (Human)

Additional RGS19 Products

Product Documents for RGS19 Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for RGS19 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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