SIGLECL12 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-38557

Novus Biologicals, part of Bio-Techne
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NBP3-38557-100ul
NBP3-38557-20ul
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Key Product Details

Species Reactivity

Mouse

Applications

ELISA, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all Siglec-12 Antibodies »

Product Specifications

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 20-210 of human SIGLECL12 (NP_443729.1).

Sequence:
EQKDYLLTMQKSVTVQEGLCVSVLCSFSYPQNGWTASDPVHGYWFRAGDHVSRNIPVATNNPARAVQEETRDRFHLLGDPQNKDCTLSIRDTRESDAGTYVFCVERGNMKWNYKYDQLSVNVTASQDLLSRYRLEVPESVTVQEGLCVSVPCSVLYPHYNWTASSPVYGSWFKEGADIPWDIPVATNTPSG

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

65 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Applications for SIGLECL12 Antibody

Application
Recommended Usage

Western Blot

1:500 - 1:2000

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS (pH 7.3), 50% glycerol

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: Siglec-12

Sialic acid-binding immunoglobulin-like lectins (SIGLECs) are a family of cell surface proteins belonging to theimmunoglobulin superfamily. They mediate protein-carbohydrate interactions by selectively binding to different sialicacid moieties present on glycolipids and glycoproteins. This gene encodes a member of the SIGLEC3-like subfamily ofSIGLECs. Members of this subfamily are characterized by an extracellular V-set immunoglobulin-like domain followed bytwo C2-set immunoglobulin-like domains, and the cytoplasmic tyrosine-based motifs ITIM and SLAM-like. The encodedprotein, upon tyrosine phosphorylation, has been shown to recruit the Src homology 2 domain-containingprotein-tyrosine phosphatases SHP1 and SHP2. It has been suggested that the protein is involved in the negativeregulation of macrophage signaling by functioning as an inhibitory receptor. This gene is located in a cluster withother SIGLEC3-like genes on 19q13.4. Alternatively spliced transcript variants encoding distinct isoforms have beendescribed for this gene. (provided by RefSeq)

Long Name

Sialic Acid Binding Ig-like Lectin 12

Alternate Names

S2V, Siglec-XII, SIGLECL1, SLG

Gene Symbol

SIGLEC12

Additional Siglec-12 Products

Product Documents for SIGLECL12 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for SIGLECL12 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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