TAB1 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-20552

Novus Biologicals, part of Bio-Techne
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NBP2-20552
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Chicken (90%), Mouse (96%), Porcine (96%), Rat (95%), Rhesus Macaque (100%). Backed by our 100% Guarantee.

Applications

Immunocytochemistry/ Immunofluorescence, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all TAB1 Antibodies »

Product Summary for TAB1 Antibody

Immunogen

Recombinant protein encompassing a sequence within the center region of human TAB1. The exact sequence is proprietary.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

55 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for TAB1 Antibody

Western Blot: TAB1 Antibody [NBP2-20552]

Western Blot: TAB1 Antibody [NBP2-20552]

Western Blot: TAB1 Antibody [NBP2-20552] - Expression in transfected 293T cell line by MAP3K7IP1 polyclonal antibody. A: Non-transfected lysate. B: TAB1 transfected lysate. 12% SDS PAGE gel, diluted at 1:500.
Immunocytochemistry/ Immunofluorescence: TAB1 Antibody [NBP2-20552]

Immunocytochemistry/ Immunofluorescence: TAB1 Antibody [NBP2-20552]

Immunocytochemistry/Immunofluorescence: TAB1 Antibody [NBP2-20552] - Confocal immunofluorescence analysis of paraformaldehyde-fixed HeLa, using TAB1 antibody (Green) at 1:500 dilution. Alpha-tubulin filaments are labeled with Alpha-tubulin antibody (Red) at 1:2000.

Applications for TAB1 Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

1:100-1:1000

Western Blot

1:500-1:3000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Antigen Affinity-purified

Formulation

0.1M Tris (pH 7), 0.1M Glycine, 10% Glycerol

Preservative

0.01% Thimerosal

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Background: TAB1

The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq]

Long Name

TAK1-binding Protein

Alternate Names

MAP3K7IP1

Gene Symbol

TAB1

UniProt

Q15750

Additional TAB1 Products

Product Documents for TAB1 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for TAB1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause reproductive toxicity with developmental effects.  For more information go to www.P65Warnings.ca.gov.

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