Key Product Details

Validated by

Independent Antibodies

Species Reactivity

Validated:

Human, Mouse

Applications

Immunohistochemistry, Immunoprecipitation, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

1.0 mg/ml

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Product Summary for WWOX Antibody

Immunogen

The immunogen this antibody was made to, maps to a region between residue 75 to 125 of human WW Domain Containing Oxidoreductase using the numbering given in entry P_057457.1 (GeneID 51741).

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for WWOX Antibody

Western Blot: WWOX Antibody [NBP2-32121]

Western Blot: WWOX Antibody [NBP2-32121]

Western Blot: WWOX Antibody [NBP2-32121] - Samples: Whole cell lysate (1 mg for IP; 20% of IP loaded) from Jurkat cells. Antibodies: Affinity purified rabbit anti-WWOX antibody NBP2-32121 used for IP at 6 ug/mg lysate. WWOX was also immunoprecipitated by rabbit anti-WWOX antibody NBP2-32121. For blotting immunoprecipitated WWOX, NBP2-32121 was used at 0.4 ug/ml. Detection: Chemiluminescence with an exposure time of 10 seconds.
Immunohistochemistry: WWOX Antibody [NBP2-32121]

Immunohistochemistry: WWOX Antibody [NBP2-32121]

Immunohistochemistry: WWOX Antibody [NBP2-32121] - Samples: FFPE serial sections of mouse renal cell carcinoma. Antibody: Affinity purified rabbit anti- WWOX used at a dilution of 1:1,000 (1ug/ml). Detection: DAB. Counterstain: Hematoxylin (blue).
Immunohistochemistry: WWOX Antibody [NBP2-32121]

Immunohistochemistry: WWOX Antibody [NBP2-32121]

Immunohistochemistry: WWOX Antibody [NBP2-32121] - Samples: FFPE serial sections of human breast carcinoma. Antibody: Affinity purified rabbit anti- WWOX used at a dilution of 1:1,000 (1ug/ml). Detection: DAB. Counterstain: Hematoxylin (blue).

Applications for WWOX Antibody

Application
Recommended Usage

Immunoprecipitation

2 - 10 mcg/mg lysate
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris-Citrate/Phosphate (pH 7.0 - 8.0)

Preservative

0.09% Sodium Azide

Concentration

1.0 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C. Do not freeze.

Background: WWOX

WW domain-containing oxidoreductase (WWOX) is a proapoptotic protein and a tumor suppressor gene. Because mutation or deletion in the coding region of WWOX is rarely found, it is speculated that the appearance of aberrant transcripts affects progression of many cancers. In addition, protein levels of WWOX, its Tyr33-phosphorylated form, and WOX2 are significantly down-regulated in the neurons of Alzheimer's hippocampi.

Long Name

WW Domain Containing Oxidoreductase

Alternate Names

FOR, FRA16D, SDR41C1, WOX1

Gene Symbol

WWOX

UniProt

P_057457.1 (Human)

Additional WWOX Products

Product Documents for WWOX Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for WWOX Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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