BDY FL Thalidomide
Tocris Bioscience, part of Bio-Techne | Catalog # 7633
Key Product Details
| Description: | High affinity fluorescent probe for TR-FRET cereblon binding assay |
| Chemical Name: | 3-(5,5-Difluoro-7,9-dimethyl-5H-5λ4,6λ4-dipyrrolo[1,2-c:2',1'-f][1,3,2]diazaborinin-3-yl)-N-(8-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)octyl)propenamide |
| Purity: | ≥95% (HPLC) |
| Molecular Weight: | 732.59 |
Biological Activity for BDY FL Thalidomide
BDY FL Thalidomide is a high-affinity fluorescent probe (Kd = 3.6 nM). It can be used in time-resolved fluorescence resonance energy-transfer (TR-FRET) cereblon binding assays for PROTAC® Degrader development. This assay is highly sensitive, selective, and stable. Excitation and emission maxima (λ) are 502 and 510 nm, respectively.
PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
Optical Data for BDY FL Thalidomide
| λabs | 502 nm |
|---|---|
| λem | 510 nm |
| Closest Laser line | 488 nm |
| Application | Time-resolved fluorescence energy transfer (TR-FRET) |
| Alternative For | FAM; Alexa Fluor 488; DyLight 488; Cy2 |
Alexa Fluor® is a registered trademark of Molecular Probes, Inc, a Thermo Fisher Scientific Company.
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