FFN 102 mesylate

Name: FFN 102 mesylate
Brand: Tocris Bioscience
SKU: 5200

Tocris Bioscience, part of Bio-Techne | Catalog # 5200

COA / SDS

Selective fluorescent substrate of DAT and VMAT2

Key Product Details

Description:	Selective fluorescent substrate of DAT and VMAT2
Chemical Name:	4-(2-Aminoethyl)-6-chloro-7-hydroxy-2H-1-benzopyran-2-one methanesulfonate
Purity:	≥99% (HPLC)
Molecular Weight:	335.76

View Full Technical Details for FFN 102 mesylate

Technical Data
Citations

Biological Activity for FFN 102 mesylate

FFN 102 mesylate is a pH responsive fluorescent false neurotransmitter (FFN). Selective dopamine transporter (DAT) and VMAT2 substrate. Exhibits no significant binding to a panel of 38 CNS receptors, including dopamine and serotonin receptors. Inhibits dopamine uptake. Excitation maxima are 340 nm at pH 5 and 370 nm at pH 7.5. Emission maximum is 435 nm at both pH 5 and 7.5.

Licensing Information

Sold with the permission of Columbia University.

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Technical Data for FFN 102 mesylate

M. Wt	335.76
Formula	C₁₁H₁₁N₂ClO₃.CH₃SO₃H
Storage	Desiccate at +4°C
Purity	≥99% (HPLC)
CAS Number	1883548-92-2
PubChem ID	91691121
InChi Key	ZEZDFYRVIVZPAT-UHFFFAOYSA-N
Smiles	ClC1=C(O)C=C(OC(C=C2CCN)=O)C2=C1.CS(=O)(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for FFN 102 mesylate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	6.72	20 with gentle warming
	DMSO	33.58	100

Preparing Stock Solutions for FFN 102 mesylate

The following data is based on the product molecular weight 335.76.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.98 mL	14.89 mL	29.78 mL
5 mM	0.60 mL	2.98 mL	5.96 mL
10 mM	0.30 mL	1.49 mL	2.98 mL
50 mM	0.06 mL	0.30 mL	0.60 mL

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References for FFN 102 mesylate

References are publications that support the biological activity of the product.

Sames Visualizing neurotransmitter secretion at individual synapses. ACS Chem.Neurosci. 2013 PMID: 23862751
Lee Development of pH-responsive fluorescent false neurotransmitters. J.Am.Chem.Soc. 2010 PMID: 20540519
Rodriguez Fluorescent DA tracer resolves individual DArgic synapses and their activity in the brain. Proc.Natl.Acad.Sci.U.S.A. 2013 PMID: 23277566