R-BC154

Name: R-BC154
Brand: Tocris Bioscience
SKU: 6048

Tocris Bioscience, part of Bio-Techne | Catalog # 6048

COA / SDS

High affinity fluorescent α4β1/α9β1 inhibitor; mobilizes HSCs

Discontinued Product

6048 has been discontinued. View all Integrin Receptor Inhibitors products.

Key Product Details

Description:	High affinity fluorescent α4β1/α9β1 inhibitor; mobilizes HSCs
Chemical Name:	(4R)-4-[4-[[[[4-[3,6-Bis(diethylamino)xanthylium-9-yl]-3-sulfophenyl]sulfonyl]amino]methyl]-1H-1,2,3-triazol-1-yl]-1-(phenylsulfonyl)-L-prolyl-O-(1-pyrrolidinyl)-L-tyrosine acetate
Purity:	≥97% (HPLC)
Molecular Weight:	1212.37

View Full Technical Details for R-BC154

Technical Data
Citations

Biological Activity for R-BC154

R-BC154 is a high affinity fluorescent α4β1/α9β1 inhibitor (K_d values are 12.7 and 38 nM, respectively); fluorescent version of BOP (Cat.No. 6047). Rapidly and preferentially mobilizes HSCs and progenitors in vivo. Excitation maximum, 561 nm; emissiosn maximum, 585 nm.

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Technical Data for R-BC154

M. Wt	1212.37
Formula	C₅₅H₆₁N₉O₁₃S₃.CH₃CO₂H
Storage	Store at -20°C
Purity	≥97% (HPLC)
PubChem ID	131648245
InChi Key	HZQNIDGYMDDNNP-MOVBADFXSA-N
Smiles	CCN(C1=CC2=[O+]C3=C(C(C4=C(S([O-])(=O)=O)C=C(S(=O)(NCC5=CN([C@@H]6C[C@@H](C(N[C@H](C(O)=O)CC7=CC=C(C=C7)OC(N8CCCC8)=O)=O)N(S(=O)(C9=CC=CC=C9)=O)C6)N=N5)=O)C=C4)=C2C=C1)C=CC(N(CC)CC)=C3)CC.CC(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for R-BC154

References are publications that support the biological activity of the product.

Cao Therapeutic targeting and rapid mobilization of endosteal HSC using a small molecule integrin antagonist. Nat.Commun. 2016 PMID: 26975966
Cao Design, synthesis and binding properties of a fluorescent α9β1/α4β1 integrin antagonist and its application as an in vivo probe for bone marrow haemopoietic stem cells. Org.Biomol.Chem. 2014 PMID: 24363056