RMR-Tre
Tocris Bioscience, part of Bio-Techne | Catalog # 8013
Key Product Details
| Description: | Far-red fluorogenic trehalose probe for live mycobacteria imaging |
| Chemical Name: | 3-(6-(5-(2,2-Dicyanovinyl)thiophen-2-yl)-3,4-dihydroquinolin-1(2H)-yl)-N-(((2R,3S,4S,5R,6R)-3,4,5-trihydroxy-6-(((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)methyl)propanamide |
| Purity: | ≥95% (HPLC) |
| Molecular Weight: | 686.73 |
Biological Activity for RMR-Tre
RMR-Tre is a far-red fluorogenic trehalose specific probe for live mycobacteria imaging. It enables fast, no-wash, low-background fluorescence detection of live mycobacterial outer membrane. RMR-Tre contains a molecular rotor fluorophore that brightly emits signal in the far-red region upon trehalose-guided metabolic integration into the mycomembrane. It exhibited up to a 100- fold enhancement in Mycobacterium tuberculosis labeling compared to existing fluorogenic trehalose probes. Excitation and emission maxima (λ) are 549 nm and 571 nm, respectively.
Licensing Information
Sold under license from Central Michigan University
Optical Data for RMR-Tre
| Emission Color | Far Red |
|---|---|
| λabs | 536 nm |
| λem | 684 nm |
| Closest Laser line | 540 nm |
|
Application of RMR-Tre. Image shows fluorescence detection of live mycobacterial outer membrane: M. smegmatis were incubated for 1 h in the presence of 100 μM of RMR-Tre, then directly imaged by fluorescence microscopy without washing. Scale bar: 10 μm. |
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