Simple Plex Control for Human Endoglin/CD105

Name: Simple Plex Control for Human Endoglin/CD105
Brand: ProteinSimple
SKU: 898084

ProteinSimple, part of Bio-Techne | Catalog # 898084

Product Datasheet / COA

Control for use with Human Endoglin/CD105 Simple Plex Cartridge Kit

Key Product Details

Technical Data
Citations

Summary for Simple Plex Control for Human Endoglin/CD105

INTENDED USE AND DESCRIPTION: For use a quantitative control for the determination of human Endoglin/CD105 concentrations in biological fluids. Controls are supplied lyophilized. Please refer to the lot specific certificate of analysis and Simple Plex Lyophilized Quality Control product insert for additional information.

Endoglin (CD105) is a transmembrane type III receptor for TGF-beta superfamily ligands and plays an important role in smooth muscle differentiation, angiogenesis, and neovascularization. It is highly expressed on proliferating vascular endothelial cells, chondrocytes, and syncytiotrophoblasts of term placenta. Human Endoglin haploinsufficiency can a cause the vascular disorder, hereditary hemorrhagic telangiectasia type I. Elevated levels of anti-angiogenic soluble Endoglin contribute to pathogenicity in preeclampsia. Endoglin associates with the receptors TGF-beta RII, Activin RIIA or RIIB, BMPR-IA/ALK-3, or BMPR-IB/ALK6 and enhance binding of Activin A, BMP-2, -7, -9, TGF-beta 1, or TGF-beta 3. Endoglin can either enhance or inhibit signaling through these receptor complexes.

Product Specifications for Simple Plex Control for Human Endoglin/CD105

Species	Human
Applications	Control, Simple Plex Automated Immunoassay
Source	N/A

Preparation & Storage

Shipping Conditions

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Storage

• Store lyophilized controls at 2-8 °C. Lyophilized controls are stable for up to 12 months from date of receipt.
• Reconstituted controls are stable for up to 6 months from date of preparation when stored at ≤ -70 °C. Storage at -20° C is not recommended.
• Individual frozen aliquots of low and high controls are designed as single-use entities. Thaw directly before use and discard any remaining volume.

Background: Endoglin/CD105

Item	Value
Entrez Gene IDs	2022 (Human); 13805 (Mouse); 497010 (Rat)
Alternate Names	CD105, CD105 antigen, ENDOsler-Rendu-Weber syndrome 1, ENG, Endoglin, HHT1FLJ41744, ORW, ORW1

Product Documents for Simple Plex Control for Human Endoglin/CD105

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