Simple Plex Control for Human Granzyme A

Name: Simple Plex Control for Human Granzyme A
Brand: ProteinSimple
SKU: 898410

ProteinSimple, part of Bio-Techne | Catalog # 898410

Product Datasheet / COA

Control for use with Human and Non-Human Primate Granzyme A Simple Plex Cartridge Kit

Key Product Details

Technical Data
Citations

Summary for Simple Plex Control for Human Granzyme A

INTENDED USE AND DESCRIPTION: For use a quantitative control for the determination of human and NHP Granzyme A concentrations in biological fluids. Controls are supplied lyophilized. Please refer to the lot specific certificate of analysis and Simple Plex Lyophilized Quality Control product insert for additional information.

Granzyme family serine proteases are stored in the granules of cytotoxic T lymphocytes and natural killer cells. Granzymes contain one S1 protease domain and are synthesized as preproproteins. Granzymes are released toward pathogen infected or transformed target cells during cellular immune reactions. Target cell entry by granzymes is through perforin channels. Granzymes trigger apoptosis by caspase-dependent and -independent mechanisms. There are five granzymes (A, B, G, H and K) in human and many more in mouse and rat.

Product Specifications for Simple Plex Control for Human Granzyme A

Species	Human, Non-human Primate
Applications	Control, Simple Plex Automated Immunoassay
Source	N/A

Preparation & Storage

Shipping Conditions

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Storage

• Store lyophilized controls at 2-8 °C. Lyophilized controls are stable for up to 12 months from date of receipt.
• Reconstituted controls are stable for up to 6 months from date of preparation when stored at ≤ -70 °C. Storage at -20° C is not recommended.
• Individual frozen aliquots of low and high controls are designed as single-use entities. Thaw directly before use and discard any remaining volume.

Background: Granzyme A

Item	Value
Entrez Gene IDs	3001 (Human); 14938 (Mouse); 266708 (Rat)
Alternate Names	CTL Tryptase, CTLA3, CTLA3Granzyme A (Cytotoxic T-lymphocyte-associated serine esterase-3; Hanukah factorserine protease), Cytotoxic T-lymphocyte proteinase 1, EC 3.4.21, Fragmentin-1, GZMA, Granzyme A, Granzyme-1, H factor, HF, HFSP, HFSPEC 3.4.21.78, Hanukkah factor, granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)

Product Documents for Simple Plex Control for Human Granzyme A

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