Simple Plex Human Caspase-1 Cartridge (2nd Gen)

Name: Simple Plex Human Caspase-1 Cartridge (2nd Gen)
Brand: ProteinSimple
SKU: SPCKB-PS-003613

ProteinSimple, part of Bio-Techne | Catalog # SPCKB-PS-003613

Simple Plex Human Caspase-1 assay kit for use on Ella instrument. Contains cartridge, sample diluent SD13, and wash buffer.

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Key Product Details

*The Sample Volume represented is based on the amount of sample incorporated into the reaction after taking into account the assay’s minimum required dilution for a given matrix. Serial dilution may be necessary to achieve some of the final sample volumes represented.

View Full Technical Details for Simple Plex Human Caspase-1 Cartridge (2nd Gen)

Technical Data
Citations

Product Specifications for Simple Plex Human Caspase-1 Cartridge (2nd Gen)

Assay Type	Automated sandwich ELISA
Format	Microfluidic cartridge containing three Glass Nano Reactors (GNR)
Reactivity	Human

Linearity

Scientific Data Examples for Simple Plex Human Caspase-1 Cartridge (2nd Gen)

	Human Caspase-1 Simple Plex Assay Standard Curve

Preparation and Storage

Shipping	The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage	Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Background: Caspase-1

Caspases are a family of cytosolic aspartate-specific cysteine proteases involved in the initiation and execution of apoptosis. They are expressed as latent zymogens and are activated by an autoproteolytic mechanism or by processing by other proteases (frequently other caspases). Human caspases can be subdivided into three functional groups: cytokine activation (caspase-1, -4, -5, and -13), apoptosis initiation (caspase-2, -8, -9, -and -10), and apoptosis execution (caspase-3, -6, and -7).

Caspases are regulated by a variety of stimili, including APAF1, CFLAR/FLIP, NOL3/ARC, and members of the inhibitor of apoptosis (IAP) family such as BIRC1/NAIP, BIRC2/cIAP-1, BIRC3/cIAP-2, BIRC4/XIAP, BIRC5/Survivin, and BIRC7/Livin. IAP activity is modulated by DIABLO/SMAC or PRSS25/HTRA2/Omi. Cell-permeable and irreversible peptide inhibitors are also available for different caspases.

Item	Value
Entrez Gene IDs	834 (Human)
Alternate Names	CASP-1, CASP1, CASP1 nirs variant 1, Caspase-1, Caspase-1 subunit p10, Caspase-1 subunit p20, Caspase1, EC 3.4.22.36, EC:3.4.22.36, ICE, IL-1 beta-converting enzyme, IL-1BC, IL1B-convertase, IL1BC, IL1BCE, Interleukin-1 beta convertase, Interleukin-1 beta-converting enzyme, caspase 1, apoptosis-related cysteine peptidase, interleukin 1, beta, convertase, interleukin 1-B converting enzyme, p45

Compatible Instruments

Ella - Automated Immunoassay Platform | ProteinSimple

Ella from ProteinSimple, a Bio-Techne brand. Get single or multiplex immunoassay results in less than 90 minutes that are consistent and highly reproducible.

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Product Documents for Simple Plex Human Caspase-1 Cartridge (2nd Gen)

Product Datasheets

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COA

Protocols & Manuals

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