1-EBIO

Name: 1-EBIO
Brand: Tocris Bioscience
SKU: 1041
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1041

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Citations (68)

COA / SDS

Epithelial KCa channel activator

Key Product Details

Description:	Epithelial K_Ca channel activator
Chemical Name:	1-Ethyl-2-benzimidazolinone
Purity:	≥99% (HPLC)
Molecular Weight:	162.19

View Full Technical Details for 1-EBIO

Technical Data
Citations / Reviews (1)

Biological Activity for 1-EBIO

1-EBIO is an activator of epithelial K_Ca channels, stimulates a large and sustained trans-epithelial Cl^- secretory response across T84 monolayers. Induces hyperpolarization to the same magnitude as ACh in aortic value endothelial cells. Promotes embryonic stem cell (ESC) differentiation into cardiomyocytes.

Compound Libraries for 1-EBIO

1-EBIO is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.

Technical Data for 1-EBIO

M. Wt	162.19
Formula	C₉H₁₀N₂O
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	10045-45-1
PubChem ID	82320
InChi Key	CXUCKELNYMZTRT-UHFFFAOYSA-N
Smiles	CCN1C(=O)NC2=C1C=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for 1-EBIO

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	16.22	100
	DMSO	16.22	100

Preparing Stock Solutions for 1-EBIO

The following data is based on the product molecular weight 162.19.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	6.17 mL	30.83 mL	61.66 mL
5 mM	1.23 mL	6.17 mL	12.33 mL
10 mM	0.62 mL	3.08 mL	6.17 mL
50 mM	0.12 mL	0.62 mL	1.23 mL

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Reconstitution Calculator

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References for 1-EBIO

References are publications that support the biological activity of the product.

Kleger Modulation of calcium-activated potassium channels induces cardiogenesis of pluripotent stem cells and enrichment of pacemaker-like cells. Circulation. 2010 PMID: 20956206
Devor Modulation of Cl^- secretion by benzimidazolones. I. Direct activation of a Ca²⁺ - dependent K⁺ channel. Am.J.Physiol. 1996 PMID: 8944721
Kusama Reduced hyperpolarisation in endothelial cells of rabbit aortic value following chronic nitroglycerine administration. Br.J.Pharmacol. 2005 PMID: 16056232
Ayotunde and Adeagbo 1-Ethyl-2-benzimidazolinone stimulates endothelial K_Ca channels and nitric oxide formation in rat mesenteric vessels. Eur.J.Pharmacol. 1999 PMID: 10497901