1-Methyl-D-tryptophan

Name: 1-Methyl- D -tryptophan
Brand: Tocris Bioscience
SKU: 5698

Tocris Bioscience, part of Bio-Techne | Catalog # 5698

Citations (7)

COA / SDS

Indoleamine 2,3-dioxygenase (IDO) inhibitor

Key Product Details

Description:	Indoleamine 2,3-dioxygenase (IDO) inhibitor
Alternative Names:	1MT
Purity:	≥97% (HPLC)
Molecular Weight:	218.25

View Full Technical Details for 1-Methyl-D-tryptophan

Technical Data
Citations

Biological Activity for 1-Methyl-D-tryptophan

1-Methyl-D-tryptophan is an indoleamine 2,3-dioxygenase (IDO) inhibitor (IC₅₀ = 7 μM); disrupts tryptophan catabolism. Enhances the antitumor and antiviral immunoresponses of CD8+ T-cells in vitro. Reduces tumor volume in mice with xenografts overexpressing IDO.

Technical Data for 1-Methyl-D-tryptophan

M. Wt	218.25
Formula	C₁₂H₁₄N₂O₂
Storage	Store at -20°C
Purity	≥97% (HPLC)
CAS Number	110117-83-4
PubChem ID	405012
InChi Key	ZADWXFSZEAPBJS-SNVBAGLBSA-N
Smiles	CN1C=C(C[C@H](C(O)=O)N)C2=CC=CC=C21

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for 1-Methyl-D-tryptophan

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	1.09	5 with gentle warming

Preparing Stock Solutions for 1-Methyl-D-tryptophan

The following data is based on the product molecular weight 218.25.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.05 mM	91.64 mL	458.19 mL	916.38 mL
0.25 mM	18.33 mL	91.64 mL	183.28 mL
0.5 mM	9.16 mL	45.82 mL	91.64 mL
2.5 mM	1.83 mL	9.16 mL	18.33 mL

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Reconstitution Calculator

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References for 1-Methyl-D-tryptophan

References are publications that support the biological activity of the product.

Rytelewski Suppression of immunodominant antitumor and antiviral CD8+ T cell responses by indoleamine 2,3-dioxygenase. PLoS One 2014 PMID: 24587363
Nakamura Effects of indoleamine 2,3-dioxygenase inhibitor in non-Hodgkin lymphoma model mice. Int.J.Hematol. 2015 PMID: 26243621