10058-F4

Name: 10058-F4
Brand: Tocris Bioscience
SKU: 4406
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 4406

(1)

Citations (20)

COA / SDS

Inhibits c-Myc-Max dimerization

Key Product Details

Description:	Inhibits c-Myc-Max dimerization
Chemical Name:	5-[(4-Ethylphenyl)methylene]-2-thioxo-4-thiazolidinone
Purity:	≥99% (HPLC)
Molecular Weight:	249.35

View Full Technical Details for 10058-F4

Technical Data
Citations / Reviews (1)

Biological Activity for 10058-F4

10058-F4 is a cell permeable c-Myc-Max dimerization inhibitor. Inhibits proliferation, induces apoptosis and arrests cells in G₀/G₁ in rat1a-c-Myc cells. Also reduces tumor growth in vivo. In lymphoma cells, 10058-F4 decreases glucose uptake and expression of glycolysis-associated genes and reduces cell viability.

Compound Libraries for 10058-F4

10058-F4 is also offered as part of the Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for 10058-F4

M. Wt	249.35
Formula	C₁₂H₁₁NOS₂
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	403811-55-2
PubChem ID	1271002
InChi Key	SVXDHPADAXBMFB-JXMROGBWSA-N
Smiles	O=C(NC(S2)=S)/C2=C\C1=CC=C(CC)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for 10058-F4

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	24.93	100
	ethanol	4.99	20

Preparing Stock Solutions for 10058-F4

The following data is based on the product molecular weight 249.35.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.01 mL	20.05 mL	40.10 mL
5 mM	0.80 mL	4.01 mL	8.02 mL
10 mM	0.40 mL	2.01 mL	4.01 mL
50 mM	0.08 mL	0.40 mL	0.80 mL

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References for 10058-F4

References are publications that support the biological activity of the product.

Broecker-Preuss Regulation of glucose uptake in lymphoma cell lines by c-MYC- and PI3K-dependent signaling pathways and impact of glycolytic pathways on cell viability J.Transl.Med. 2017 PMID: 28724379
Huang A small-molecule c-Myc inhibitor, 10058-F4, induces cell-cycle arrest, apoptosis, and myeloid differentiation of human acute myeloid leukemia. Exp.Hematol. 2006 PMID: 17046567
Guo Efficacy, pharmacokinetics, tisssue distribution, and metabolism of the Myc-Max disruptor, 10058-F4 [Z,E]-5-[4-ethylbenzylidine]-2-thioxothiazolidin-4-one, in mice. Cancer Chemother.Pharmacol. 2009 PMID: 18509642
Yin Low molecular weight inhibitors of Myc-Max interaction and function. Oncogene 2003 PMID: 13679853