10058-F4

Name: 10058-F4
Brand: Tocris Bioscience
SKU: 4406

Tocris Bioscience, part of Bio-Techne | Catalog # 4406

(1)

Citations (19)

COA / SDS

Inhibits c-Myc-Max dimerization

Key Product Details

Chemical Name:	5-[(4-Ethylphenyl)methylene]-2-thioxo-4-thiazolidinone
Purity:	≥99%

View Full Technical Details for 10058-F4

Technical Data
Citations / Reviews (1)

Biological Activity for 10058-F4

10058-F4 is a cell permeable c-Myc-Max dimerization inhibitor. Inhibits proliferation, induces apoptosis and arrests cells in G₀/G₁ in rat1a-c-Myc cells. Also reduces tumor growth in vivo. In lymphoma cells, 10058-F4 decreases glucose uptake and expression of glycolysis-associated genes and reduces cell viability.

Technical Data for 10058-F4

Formula	C₁₂H₁₁NOS₂
Storage	Store at +4°C
Purity	≥99%
CAS Number	403811-55-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for 10058-F4

Solubility

Soluble Soluble to 100 mM in DMSO and to 20 mM in ethanol

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References for 10058-F4

References are publications that support the biological activity of the product.

Yin et al. Low molecular weight inhibitors of Myc-Max interaction and function. Oncogene, 2003;22:6151 PMID: 13679853
Guo et al. Efficacy, pharmacokinetics, tisssue distribution, and metabolism of the Myc-Max disruptor, 10058-F4 [Z,E]-5-[4-ethylbenzylidine]-2-thioxothiazolidin-4-one, in mice. Cancer Chemother.Pharmacol., 2009;63:615 PMID: 18509642
Huang et al. A small-molecule c-Myc inhibitor, 10058-F4, induces cell-cycle arrest, apoptosis, and myeloid differentiation of human acute myeloid leukemia. Exp.Hematol., 2006;34:1480 PMID: 17046567

10058-F4

Tocris Bioscience, part of Bio-Techne | Catalog # 4406

Key Product Details

Biological Activity for 10058-F4

Technical Data for 10058-F4

Solubility for 10058-F4

Dilution Calculator

Reconstitution Calculator

References for 10058-F4

Product Documents for 10058-F4

COA

Certificate of Analysis

SDS

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