¹⁰Panx

Name: 10 Panx
Brand: Tocris Bioscience
SKU: 3348

Tocris Bioscience, part of Bio-Techne | Catalog # 3348

Citations (31)

COA / SDS

Panx-1 mimetic inhibitory peptide; blocks pannexin-1 gap junctions

Key Product Details

Description:	Panx-1 mimetic inhibitory peptide; blocks pannexin-1 gap junctions
Purity:	≥95% (HPLC)
Molecular Weight:	1242.37

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Technical Data
Citations

Biological Activity for ¹⁰Panx

¹⁰Panx is a panx-1 mimetic inhibitory peptide that blocks pannexin-1 gap junctions. Inhibits P2X₇-mediated dye uptake, ATP-mediated IL-1β release and caspase-1 activation without altering membrane current in macrophages in vitro. Also blocks activation of NMDA receptor secondary currents (I_2nd) by > 70%.

Technical Data for ¹⁰Panx

M. Wt	1242.37
Formula	C₅₈H₇₉N₁₅O₁₆
Single Letter Sequence	WRQAAFVDSY
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	955091-53-9
PubChem ID	44233736
InChi Key	JCJASTVQGSKHKZ-QZHJRRRASA-N
Smiles	[H]N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ¹⁰Panx

Solubility

Soluble to 1mg/ml in water

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References for ¹⁰Panx

References are publications that support the biological activity of the product.

Wang Modulation of membrane channel currents by gap junction protein mimetic peptides: size matters. Am.J.Physiol.Cell Physiol. 2007 PMID: 17652431
Thompson Activation of pannexin-1 hemichannels augments aberrant bursting in the hippocampus. Science 2008 PMID: 19056988
Pelegrin and Surprenant Pannexin-1 mediates large pore formation and interleukin-1β; release by the ATP-gated P2X₇ receptor. EMBO J. 2006 PMID: 17036048

¹⁰Panx

Tocris Bioscience, part of Bio-Techne | Catalog # 3348

Key Product Details

Biological Activity for ¹⁰Panx

Technical Data for ¹⁰Panx

Solubility for ¹⁰Panx

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for ¹⁰Panx

Product Documents for ¹⁰Panx

COA

Certificate of Analysis

SDS

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10Panx

Tocris Bioscience, part of Bio-Techne | Catalog # 3348

Key Product Details

Biological Activity for 10Panx

Technical Data for 10Panx

Solubility for 10Panx

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for 10Panx

Product Documents for 10Panx

COA

Certificate of Analysis

SDS

¹⁰Panx

Biological Activity for ¹⁰Panx

Technical Data for ¹⁰Panx

Solubility for ¹⁰Panx

References for ¹⁰Panx

Product Documents for ¹⁰Panx