2',3'-cGAMP sodium salt

Name: 2',3'-cGAMP sodium salt
Brand: Tocris Bioscience
SKU: 5945

Tocris Bioscience, part of Bio-Techne | Catalog # 5945

Citations (2)

COA / SDS

Endogenous high affinity STING agonist

Key Product Details

Description:	Endogenous high affinity STING agonist
Chemical Name:	2',3'-Cyclic guanosine monophosphate-adenosine monophosphate sodium salt
Purity:	≥98% (HPLC)
Molecular Weight:	718.37

View Full Technical Details for 2',3'-cGAMP sodium salt

Technical Data
Citations

Biological Activity for 2',3'-cGAMP sodium salt

2',3'-cGAMP sodium salt is a endogenous high affinity STING agonist (K_d values are 3.79 and 120 nM for human and rat STING, respectively). Induces repolarization of M2 macrophages in vitro.

This product is sold in units of 359μg, equivalent to 0.5μmol.

Technical Data for 2',3'-cGAMP sodium salt

M. Wt	718.37
Formula	C₂₀H₂₂N₁₀Na₂O₁₃P₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2734858-36-5
PubChem ID	71563406
InChi Key	XRILCFTWUCUKJR-INFSMZHSSA-N
Smiles	[H][C@]12COP(O[C@]3([C@H]([C@H](N4C=NC5=C(N=CN=C45)N)O[C@@]3(COP(O[C@@]([C@H](N6C=NC7=C6N=C(NC7=O)N)O1)([C@@H]2O)[H])(O[Na])=O)[H])O)[H])(O[Na])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for 2',3'-cGAMP sodium salt

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	35.92	50

Preparing Stock Solutions for 2',3'-cGAMP sodium salt

The following data is based on the product molecular weight 718.37.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	2.78 mL	13.92 mL	27.84 mL
2.5 mM	0.56 mL	2.78 mL	5.57 mL
5 mM	0.28 mL	1.39 mL	2.78 mL
25 mM	0.06 mL	0.28 mL	0.56 mL

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References for 2',3'-cGAMP sodium salt

References are publications that support the biological activity of the product.

Downey DMXAA causes tumor site-specific vascular disruption in murine non-small cell lung cancer, and like the endogenous non-canonical cyclic dinucleotide STING agonist, 2'3'-cGAMP, induces M2 macrophage repolarization. PLoS One 2014 PMID: 24940883
Zhang Rat and human STINGs profile similarly towards anticancer/antiviral compounds. Sci.Rep. 2015 PMID: 26669264
Zhang Cyclic GMP-AMP containing mixed phosphodiester linkages is an endogenous high-affinity ligand for STING. Mol.Cell. 2013 PMID: 23747010