2-Arachidonylglycerol

Name: 2-Arachidonylglycerol
Brand: Tocris Bioscience
SKU: 1298
Rating: 4 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1298

(1)

Citations (29)

COA / SDS

Endogenous and non-selective CB agonist; potent GPR55 agonist

Key Product Details

Description:	Endogenous and non-selective CB agonist; potent GPR55 agonist
Alternative Names:	2-AG,Arachidonoylglycerol
Chemical Name:	(5Z,8Z,11Z,14Z)-5,8,11,14-Eicosatetraenoic acid, 2-hydroxy-1-(hydroxymethyl)ethyl ester
Molecular Weight:	378.55

View Full Technical Details for 2-Arachidonylglycerol

Technical Data
Citations / Reviews (1)

Biological Activity for 2-Arachidonylglycerol

2-Arachidonylglycerol is a endogenous cannabinoid ligand that acts as a potent agonist at GPR55 (EC₅₀ values are 3, 519 and 618 nM at GPR55, CB₁ and CB₂ respectively; K_i values are 472 and 1400 nM at CB₁ and CB₂ respectively). Found in the brain at concentrations 1000-fold higher than that of anandamide. Effects are enhanced by combined administration with 2-palmitoylglycerol (Cat. No. 2206) in vivo. Also antagonizes bacterial quorum sensing receptor QseC. Protects mice from enteric infection by Enterobacteriaceae pathogens.

Technical Data for 2-Arachidonylglycerol

M. Wt	378.55
Formula	C₂₃H₃₈O₄
Storage	Store at -80°C
CAS Number	53847-30-6
PubChem ID	5282280
InChi Key	RCRCTBLIHCHWDZ-DOFZRALJSA-N
Smiles	O=C(OC(CO)CO)CCC\C=C/C\C=C/C/C=C\C/C=C\CCCCC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for 2-Arachidonylglycerol

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	37.85	100
	DMSO	37.85	100

Preparing Stock Solutions for 2-Arachidonylglycerol

The following data is based on the product molecular weight 378.55.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.64 mL	13.21 mL	26.42 mL
5 mM	0.53 mL	2.64 mL	5.28 mL
10 mM	0.26 mL	1.32 mL	2.64 mL
50 mM	0.05 mL	0.26 mL	0.53 mL

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Reconstitution Calculator

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References for 2-Arachidonylglycerol

References are publications that support the biological activity of the product.

Ellermann Endocannabinoids inhibit the induction of virulence in enteric pathogens. Cell 2020 PMID: 33031742
Sugiura Evidence that 2-arachidonoylglycerol but not N-palmitoylethanolamine or anandamide is the physiological ligand for the cannabinoid CB₂ receptor. J.Biol.Chem. 2000 PMID: 10617657
Ryberg The orphan receptor GPR55 is a novel cannabinoid receptor. Br.J.Pharmacol. 2007 PMID: 17876302
Sugiura Evidence that the cannabinoid CB1 receptor is a 2-arachidonoylglycerol receptor. J.Biol.Chem. 1999 PMID: 9915812
Mechoulam Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors. Biochem.Pharmacol. 1995 PMID: 7605349