3-Bromocytisine

Name: 3-Bromocytisine
Brand: Tocris Bioscience
SKU: 3549

Tocris Bioscience, part of Bio-Techne | Catalog # 3549

Citations (2)

COA / SDS

Potent α4β4, α4β2 and α7 nAChR agonist

Key Product Details

Chemical Name:	(1R,5S)-9-Bromo-1,2,3,4,5,6-hexahydro-1,5-methano-8H-pyrido[1,2-a][1,5]diazocin-8-one
Purity:	≥98%
Molecular Weight:	269.14 kDa

View Full Technical Details for 3-Bromocytisine

Technical Data
Citations

Biological Activity for 3-Bromocytisine

3-Bromocytisine is a potent agonist of α4β4, α4β2 and α7 nACh receptors (IC₅₀ values are 0.28, 0.30 and 31.6 nM respectively). Displays different effects on high (HS) and low (LS) ACh sensitivity α4β2 nAChRs (EC₅₀ values are 0.008 and 0.05 μM respectively).

Technical Data for 3-Bromocytisine

M. Wt	269.14 kDa
Formula	C₁₁H₁₃BrN₂O
Storage	Store at -20°C
Purity	≥98%
CAS Number	207390-14-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for 3-Bromocytisine

Solubility

Soluble Soluble to 100 mM in water and to 100 mM in DMSO

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References for 3-Bromocytisine

References are publications that support the biological activity of the product.

Houlihan et al. Activity of cytisine and its brominated isoteres on recombinant human α7, α4β2 and α4β4 nicotinic acetylcholine receptors. J.Neurochem., 2001;78:1029 PMID: 11553677
Moroni et al. α₄β₂ nicotinic receptors with high and low acetylcholine sensitivity: pharmacology, stoichiometry, and sensitivity to long-term exposure to nicotine. Mol.Pharmacol., 2006;70:755 PMID: 16720757