4-DAMP

Tocris Bioscience, part of Bio-Techne | Catalog # 0482

COA / SDS

Muscarinic M3 antagonist

Key Product Details

Description:	Muscarinic M₃ antagonist
Chemical Name:	1,1-Dimethyl-4-diphenylacetoxypiperidinium iodide
Purity:	≥99% (HPLC)
Molecular Weight:	451.33

View Full Technical Details for 4-DAMP

Technical Data
Citations

Biological Activity for 4-DAMP

4-DAMP is an antagonist at the M₃ cholinergic receptor. [³H]-4-DAMP selectively labels M₁ and M₃ receptors.

Technical Data for 4-DAMP

M. Wt	451.33
Formula	C₂₁H₂₆INO₂
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	1952-15-4
PubChem ID	3014059
InChi Key	WWJHRSCUAQPFQO-UHFFFAOYSA-M
Smiles	[I-].C[N+]1(C)CCC(CC1)OC(=O)C(C1=CC=CC=C1)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for 4-DAMP

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	11.28	25

Preparing Stock Solutions for 4-DAMP

The following data is based on the product molecular weight 451.33.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	8.86 mL	44.31 mL	88.63 mL
1.25 mM	1.77 mL	8.86 mL	17.73 mL
2.5 mM	0.89 mL	4.43 mL	8.86 mL
12.5 mM	0.18 mL	0.89 mL	1.77 mL

Molarity Calculator

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Reconstitution Calculator

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References for 4-DAMP

References are publications that support the biological activity of the product.

Michel Direct labelling of rat M₃-muscarinic receptors by [³H]4-DAMP. Eur.J.Pharmacol. 1989 PMID: 2806372
Barlow and Shepherd A further search for selective antagonists at M₂- muscarinic receptors. Br.J.Pharmacol. 1986 PMID: 3814912