4-IPP

Name: 4-IPP
Brand: Tocris Bioscience
SKU: 3429

Tocris Bioscience, part of Bio-Techne | Catalog # 3429

Citations (16)

COA / SDS

Inhibitor of macrophage migration inhibitory factor (MIF); suicide substrate

Key Product Details

Description:	Inhibitor of macrophage migration inhibitory factor (MIF); suicide substrate
Chemical Name:	4-Iodo-6-phenylpyrimidine
Purity:	≥98% (HPLC)
Molecular Weight:	282.08

View Full Technical Details for 4-IPP

Technical Data
Citations

Biological Activity for 4-IPP

4-IPP is an inhibitor of macrophage migration inhibitory factor (MIF). Acts as a suicide substrate to inactivate MIF catalytic and biological functions; inhibits MIF-associated liver enzyme activity in vivo. Also inhibits migration and anchorage independence of human lung adenocarcinoma cell lines in vitro.

Technical Data for 4-IPP

M. Wt	282.08
Formula	C₁₀H₇IN₂
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	41270-96-6
PubChem ID	817368
InChi Key	ZTCJXHNJVLUUMR-UHFFFAOYSA-N
Smiles	IC1=NC=NC(C2=CC=CC=C2)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for 4-IPP

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	28.21	100
	ethanol	14.1	50

Preparing Stock Solutions for 4-IPP

The following data is based on the product molecular weight 282.08.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.55 mL	17.73 mL	35.45 mL
5 mM	0.71 mL	3.55 mL	7.09 mL
10 mM	0.35 mL	1.77 mL	3.55 mL
50 mM	0.07 mL	0.35 mL	0.71 mL

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References for 4-IPP

References are publications that support the biological activity of the product.

Winner A novel, macrophage migration inhibitory factor suicide substrate inhibits motility and growth of lung cancer cells. Cancer Res. 2008 PMID: 18794110