5-BDBD

Tocris Bioscience, part of Bio-Techne | Catalog # 3579

(1)

Citations (95)

COA / SDS

Potent and selective P2X4 antagonist

Key Product Details

Description:	Potent and selective P2X₄ antagonist
Chemical Name:	5-(3-Bromophenyl)-1,3-dihydro-2H-benzofuro[3,2-e]-1,4-diazepin-2-one
Purity:	≥99% (HPLC)
Molecular Weight:	355.19

View Full Technical Details for 5-BDBD

Technical Data
Citations / Reviews (1)

Biological Activity for 5-BDBD

5-BDBD is a potent and selective P2X₄ receptor antagonist. Blocks P2X₄-mediated currents in Chinese hamster ovary cells (IC₅₀ = 0.50 μM). Exhibits no significant antagonist effects at other P2X receptors. Reduces long-term potentiation (LTP) in rat hippocampal slices.

Technical Data for 5-BDBD

M. Wt	355.19
Formula	C₁₇H₁₁BrN₂O₂
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	768404-03-1
PubChem ID	9841560
InChi Key	NKYMVQPXXTZHSF-UHFFFAOYSA-N
Smiles	BrC1=CC(C(C3=C4C2=C(O3)C=CC=C2)=NCC(N4)=O)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for 5-BDBD

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	35.52	100

Preparing Stock Solutions for 5-BDBD

The following data is based on the product molecular weight 355.19.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.82 mL	14.08 mL	28.15 mL
5 mM	0.56 mL	2.82 mL	5.63 mL
10 mM	0.28 mL	1.41 mL	2.82 mL
50 mM	0.06 mL	0.28 mL	0.56 mL

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Reconstitution Calculator

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References for 5-BDBD

References are publications that support the biological activity of the product.

Casati Cell-autonomous regulation of hematopoietic stem cell cycling activity by ATP. Cell Death Differ. 2011 PMID: 20798687
Coddou Characterization of the antagonist actions of 5-BDBD at the rat P2X4 receptor. Neurosci Lett. 2018 PMID: 30366010
Donnelly-Roberts Painful purinergic receptors. J.Pharmacol.Exp.Ther. 2008 PMID: 18042830