5-Iodotubercidin

Name: 5-Iodotubercidin
Brand: Tocris Bioscience
SKU: 1745

Tocris Bioscience, part of Bio-Techne | Catalog # 1745

Citations (24)

COA / SDS

Potent adenosine kinase inhibitor; also inhibits nucleoside transporters and a range of other kinases

Key Product Details

Description:	Potent adenosine kinase inhibitor; also inhibits nucleoside transporters and a range of other kinases
Chemical Name:	5-Iodo-7-β-D-ribofuranosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Purity:	≥97% (HPLC)
Molecular Weight:	392.15

View Full Technical Details for 5-Iodotubercidin

Technical Data
Citations

Biological Activity for 5-Iodotubercidin

5-Iodotubercidin is a potent adenosine kinase inhibitor (IC₅₀ = 26 nM). Also nucleoside transporter inhibitor (IC₅₀ values are < 25 nM, 7 μM and 15 μM for inhibition of [³H]adenosine, [³H]uridine and [³H]formycin B uptake respectively). Strongly stimulates glycogen synthesis in hepatocytes via activation of glycogen synthase. Also inhibits CK1, insulin receptor tyrosine kinase, phosphorylase kinase, PKA, CK2 and PKC (IC₅₀ values are 0.4, 3.5, 5-10, 5-10, 10.9 and 27.7 μM respectively). Decreases hippocampal DNA methylation through adenosine kinase inhibition in vivo.

Technical Data for 5-Iodotubercidin

M. Wt	392.15
Formula	C₁₁H₁₃IN₄O₄
Storage	Store at -20°C
Purity	≥97% (HPLC)
CAS Number	24386-93-4
PubChem ID	97297
InChi Key	WHSIXKUPQCKWBY-IOSLPCCCSA-N
Smiles	O[C@H]([C@H](O)[C@@H](CO)O3)[C@@H]3N1C2=C(C(N)=NC=N2)C(I)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for 5-Iodotubercidin

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	19.61	50

Preparing Stock Solutions for 5-Iodotubercidin

The following data is based on the product molecular weight 392.15.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.10 mL	25.50 mL	51.00 mL
2.5 mM	1.02 mL	5.10 mL	10.20 mL
5 mM	0.51 mL	2.55 mL	5.10 mL
25 mM	0.10 mL	0.51 mL	1.02 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for 5-Iodotubercidin

References are publications that support the biological activity of the product.

Williams-Karnesky Epigenetic changes induced by adenosine augmentation therapy prevent epileptogenesis. J.Clin.Invest. 2013 PMID: 23863710
Parkinson and Geiger Effects of iodotubercidin on adenosine kinase activity and nucleoside transport in DDT₁ MF-2 smooth muscle cells. J.Pharmacol.Exp.Ther. 1996 PMID: 8667202
Ugarkar Adenosine kinase inhibitors. 1. Synthesis, enzyme inhibition, and antiseizure activity of 5-iodotubercidin analogues. J.Med.Chem. 2000 PMID: 10956196
Massillon Identification of the glycogenic compound 5-iodotubercidin as a general protein kinase inhibitor. Biochem.J. 1994 PMID: 8166629