5-Ph-IAA-AM

Name: 5-Ph-IAA-AM
Brand: Tocris Bioscience
SKU: 7893

Tocris Bioscience, part of Bio-Techne | Catalog # 7893

COA / SDS

Selective and potent TAG Degrader for auxin-inducible degron 2 system; 5-Ph-IAA analog

Key Product Details

Description:	Selective and potent TAG Degrader for auxin-inducible degron 2 system; 5-Ph-IAA analog
Chemical Name:	Acetoxymethyl 2-(5-phenyl-1H-indol-3-yl)acetate
Purity:	≥98% (HPLC)
Molecular Weight:	323.35

View Full Technical Details for 5-Ph-IAA-AM

Technical Data
Citations

Biological Activity for 5-Ph-IAA-AM

5-Ph-IAA-AM is a potent and selective "Bump & Hole" TAG Degrader, for use within an auxin-inducible degron (AID2) system; it is an egg-permeant analog of 5-Ph-IAA (Cat. No. 7392). 5-Ph-IAA-AM induces selective degradation of a target protein tagged with a single-point mutant AtTIR1^F79G F-box protein. 5-Ph-IAA-AM induces target protein degradation in C. elegans embryos. No developmental abnormality is observed when the embryos are treated with 50 μM 5-Ph-IAA-AM.

Technical Data for 5-Ph-IAA-AM

M. Wt	323.35
Formula	C₁₉H₁₇NO₄
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2990123-10-7
PubChem ID	162641049
InChi Key	FGVMSTLYCNILJO-UHFFFAOYSA-N
Smiles	O=C(OCOC(C)=O)CC1=CNC2=C1C=C(C=C2)C3=CC=CC=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for 5-Ph-IAA-AM

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	32.34	100
	ethanol	3.23	10

Preparing Stock Solutions for 5-Ph-IAA-AM

The following data is based on the product molecular weight 323.35.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.09 mL	15.46 mL	30.93 mL
5 mM	0.62 mL	3.09 mL	6.19 mL
10 mM	0.31 mL	1.55 mL	3.09 mL
50 mM	0.06 mL	0.31 mL	0.62 mL

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References for 5-Ph-IAA-AM

References are publications that support the biological activity of the product.

Negishi The auxin-inducible degron 2 (AID2) system enables controlled protein knockdown during embryogenesis and development in Caenorhabditis elegans. Genetics 2022 PMID: 34865044