6,8-Bis(benzylthio)octanoic acid

Name: 6,8-Bis(benzylthio)octanoic acid
Brand: Tocris Bioscience
SKU: 5348

Tocris Bioscience, part of Bio-Techne | Catalog # 5348

Citations (4)

COA / SDS

PDH and KGDH inhibitor

Key Product Details

Description:	PDH and KGDH inhibitor
Chemical Name:	6,8-Bis[(phenylmethyl)thio]octanoic acid
Purity:	≥99% (HPLC)
Molecular Weight:	388.59

View Full Technical Details for 6,8-Bis(benzylthio)octanoic acid

Technical Data
Citations

Biological Activity for 6,8-Bis(benzylthio)octanoic acid

6,8-Bis(benzylthio)octanoic acid is a pyruvate dehydrogenase (PDH) and α-ketoglutarate dehydrogenase (KGDH) inhibitor. Disrupts tumor cell mitochondrial metabolism, and increases mitochondrial reactive oxygen species (ROS) production in H460 lung carcinoma cells. Has no effect on KGDH activity in normal bronchial epithelial cells. Induces cell death of multiple tumor cell lines selectively over normal cells in vitro. Inhibits tumor growth of H460 and BxPC-3 tumor cell xenografts in mice.

Technical Data for 6,8-Bis(benzylthio)octanoic acid

M. Wt	388.59
Formula	C₂₂H₂₈O₂S₂
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	95809-78-2
PubChem ID	24770514
InChi Key	ZYRLHJIMTROTBO-UHFFFAOYSA-N
Smiles	OC(CCCCC(SCC2=CC=CC=C2)CCSCC1=CC=CC=C1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for 6,8-Bis(benzylthio)octanoic acid

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	38.86	100
	ethanol	38.86	100

Preparing Stock Solutions for 6,8-Bis(benzylthio)octanoic acid

The following data is based on the product molecular weight 388.59.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.57 mL	12.87 mL	25.73 mL
5 mM	0.51 mL	2.57 mL	5.15 mL
10 mM	0.26 mL	1.29 mL	2.57 mL
50 mM	0.05 mL	0.26 mL	0.51 mL

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References for 6,8-Bis(benzylthio)octanoic acid

References are publications that support the biological activity of the product.

Stuart A strategically designed small molecule attacks alpha-ketoglutarate dehydrogenase in tumor cells through a redox process. Cancer Metab. 2014 PMID: 24612826
Egawa Therapeutic potential of CPI-613 for targeting tumorous mitochondrial energy metabolism and inhibiting autophagy in clear cell sarcoma. PLoS One 2018 PMID: 29879220
Zachar Non-redox-active lipoate derivates disrupt cancer cell mitochondrial metabolism and are potent anticancer agents in vivo. J.Mol.Med. (Berl.) 2011 PMID: 21769686