6-Hydroxy-DL-DOPA

Name: 6-Hydroxy- DL -DOPA
Brand: Tocris Bioscience
SKU: 5740

Tocris Bioscience, part of Bio-Techne | Catalog # 5740

Citations (2)

COA / SDS

Allosteric inhibitor of RAD52; also APE1 inhibitor

Key Product Details

Description:	Allosteric inhibitor of RAD52; also APE1 inhibitor
Chemical Name:	2,5-Dihydroxy-DL-tyrosine
Molecular Weight:	213.19

View Full Technical Details for 6-Hydroxy-DL-DOPA

Technical Data
Citations

Biological Activity for 6-Hydroxy-DL-DOPA

6-Hydroxy-DL-DOPA is an allosteric inhibitor of RAD52; inhibits RAD52 binding to single strand DNA binding domains (IC₅₀ = 1.1 μM). Selectively inhibits proliferation of BRCA-deficient cancer cells in vitro. Also inhibits APE1.

Technical Data for 6-Hydroxy-DL-DOPA

M. Wt	213.19
Formula	C₉H₁₁NO₅
Storage	Store at -20°C
CAS Number	21373-30-8
PubChem ID	107794
InChi Key	YLKRUSPZOTYMAT-UHFFFAOYSA-N
Smiles	OC1=C(O)C=C(O)C(CC(C(O)=O)N)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for 6-Hydroxy-DL-DOPA

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	1M HCl	21.32	100

Preparing Stock Solutions for 6-Hydroxy-DL-DOPA

The following data is based on the product molecular weight 213.19.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.69 mL	23.45 mL	46.91 mL
5 mM	0.94 mL	4.69 mL	9.38 mL
10 mM	0.47 mL	2.35 mL	4.69 mL
50 mM	0.09 mL	0.47 mL	0.94 mL

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References for 6-Hydroxy-DL-DOPA

References are publications that support the biological activity of the product.

Simeonov Identification and characterization of inhibitors of human apurinic/apyrimidinic endonuclease APE1. PLoS One 2009 PMID: 19484131
Chandramouly Small-Molecule Disruption of RAD52 Rings as a Mechanism for Precision Medicine in BRCA-Deficient Cancers. Chem.Biol. 2015 PMID: 26548611
Wilson DM 3rd Small molecule inhibitors of DNA repair nuclease activities of APE1. Cell Mol.Life Sci. 2010 PMID: 20809131