6-Hydroxydopamine hydrobromide

Name: 6-Hydroxydopamine hydrobromide
Brand: Tocris Bioscience
SKU: 2547
Rating: 5 (2 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 2547

(2)

Citations (17)

COA / SDS

Selective catecholaminergic neurotoxin

Key Product Details

Description:	Selective catecholaminergic neurotoxin
Alternative Names:	6-OHDA
Chemical Name:	5-(2-Aminoethyl)-1,2,4-benzenetriol hydrobromide
Molecular Weight:	250.09

View Full Technical Details for 6-Hydroxydopamine hydrobromide

Technical Data
Citations / Reviews (2)

Biological Activity for 6-Hydroxydopamine hydrobromide

6-Hydroxydopamine hydrobromide is a selective catecholaminergic neurotoxin. Depletes brain catecholamine levels via uptake and accumulation by a transport mechanism specific to these neurons. Causes almost complete destruction of nigral dopaminergic neurons and their striatal terminals when injected into the substantia nigra of rats, producing an animal model of Parkinson's disease.

Technical Data for 6-Hydroxydopamine hydrobromide

M. Wt	250.09
Formula	C₈H₁₁NO₃.HBr
Storage	Store at -20°C
CAS Number	636-00-0
PubChem ID	176170
InChi Key	MLACDGUOKDOLGC-UHFFFAOYSA-N
Smiles	NCCC1=CC(O)=C(O)C=C1O.Br

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for 6-Hydroxydopamine hydrobromide

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	20.56	100
	DMSO	20.56	100

Preparing Stock Solutions for 6-Hydroxydopamine hydrobromide

The following data is based on the product molecular weight 250.09.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.00 mL	19.99 mL	39.99 mL
5 mM	0.80 mL	4.00 mL	8.00 mL
10 mM	0.40 mL	2.00 mL	4.00 mL
50 mM	0.08 mL	0.40 mL	0.80 mL

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References for 6-Hydroxydopamine hydrobromide

References are publications that support the biological activity of the product.

Soto-Otero Autoxidation and neurotoxicity of 6-hydroxyDA in the presence of some antioxidants: potential implication in relation to the pathogenesis of Parkinson's disease. J.Neurochem. 2000 PMID: 10737618
Fujita Cell-permeable cAMP analog suppresses 6-hydroxyDA-induced apoptosis in PC12 cells through the activation of the Akt pathway. Brain Res. 2006 PMID: 16945353
Breese and Traylor Effect of 6-hydroxyDA on brain NE and DA: evidence for selective degeneration of catecholamine neurons. J.Pharmacol.Exp.Ther. 1970 PMID: 5456173