7,8-Dihydroxyflavone

Name: 7,8-Dihydroxyflavone
Brand: Tocris Bioscience
SKU: 3826

Tocris Bioscience, part of Bio-Techne | Catalog # 3826

Citations (21)

COA / SDS

TrkB agonist

Key Product Details

Description:	TrkB agonist
Alternative Names:	7,8-DHF
Chemical Name:	7,8-Dihydroxy-2-phenyl-4H-1-benzopyran-4-one
Purity:	≥98% (HPLC)
Molecular Weight:	254.24

View Full Technical Details for 7,8-Dihydroxyflavone

Technical Data
Citations

Biological Activity for 7,8-Dihydroxyflavone

7,8-Dihydroxyflavone is a tyrosine kinase receptor B (TrkB) agonist that binds to the extracellular domain of the receptor (K_d = 320 nM). Inhibits glutamate-triggered apoptosis in hippocampal neurons in vitro and in vivo. Exhibits neuroprotective effects in an HD mouse model.

Technical Data for 7,8-Dihydroxyflavone

M. Wt	254.24
Formula	C₁₅H₁₀O₄
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	38183-03-8
PubChem ID	1880
InChi Key	COCYGNDCWFKTMF-UHFFFAOYSA-N
Smiles	O=C2C1=CC=C(O)C(O)=C1OC(C3=CC=CC=C3)=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for 7,8-Dihydroxyflavone

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	25.42	100
	2eq. NaOH	25.42	100

Preparing Stock Solutions for 7,8-Dihydroxyflavone

The following data is based on the product molecular weight 254.24.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.93 mL	19.67 mL	39.33 mL
5 mM	0.79 mL	3.93 mL	7.87 mL
10 mM	0.39 mL	1.97 mL	3.93 mL
50 mM	0.08 mL	0.39 mL	0.79 mL

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References for 7,8-Dihydroxyflavone

References are publications that support the biological activity of the product.

Andero 7,8-dihydroxyflavone, a TrkB receptor agonist, blocks long-term spatial memory impairment caused by immobilzation stress in rats. Hippocampus 2012 PMID: 21136519
Jiang Small-molecule TrkB receptor agonists improve motor function and extend survival in a mouse model of Huntington's disease. Hum.Mol.Genet. 2013 PMID: 23446639
Jang A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone. Proc.Natl.Acad.Sci.USA